Fear of needles
It is occasionally referred to as aichmophobia or belonephobia, although these terms may also refer to a more general fear of sharply pointed objects. It has also been referred to as trypanophobia, although the origin and proper usage of that term is highly controversial.
Overview and incidence
The condition was officially recognized in 1994 in the DSM-IV (Diagnostic and Statistical Manual, 4th edition) as a specific phobia of blood/injection/injury type. Phobic level responses to injections cause sufferers to avoid inoculations, blood tests, and in the more severe cases, all medical care.
It is estimated that at least 10% of American adults have a fear of needles, and it is likely that the actual number is larger, as the most severe cases are never documented due to the tendency of the sufferer to avoid all medical treatment.
According to Dr. James G. Hamilton, author of the pioneering paper on needle phobia, it is likely that the form of needle phobia that is genetic has some basis in evolution, given that thousands of years ago humans who meticulously avoided stab wounds and other incidences of pierced flesh would have a greater chance of survival.
The discussion of the evolutionary basis of needle phobia in Hamilton's review article concerns the vasovagal type of needle phobia, which is a sub-type of blood-injection-injury phobia. This type of needle phobia is uniquely characterized by a two-phase vasovagal response. First, there is a brief acceleration of heart rate and blood pressure. This is followed by a rapid plunge in both heart rate and blood pressure, sometimes leading to unconsciousness. The loss of consciousness is sometimes accompanied by convulsions and numerous rapid changes in the levels of many different hormones.
Other medical journal articles have discussed additional aspects of this possible link between vasovagal syncope and evolutionary fitness in blood-injection-injury phobias.
An evolutionary psychology theory that explains the association to vasovagal syncope is that some forms of fainting are non-verbal signals that developed in response to increased inter-group aggression during the paleolithic. A non-combatant who has fainted signals that they are not a threat.  This might explain the association between fainting and stimuli such as bloodletting and injuries.
Although needle phobia is defined simply as an extreme fear of medically related shots/injections, it appears in several varieties.
Although most specific phobias stem from the individuals themselves, the most common type of needle phobia, affecting 50% of those afflicted, is an inherited vasovagal reflex reaction. Approximately 80% of people with a fear of needles report that a relative within the first degree exhibits the same disorder.
People who suffer from vasovagal needle phobia fear the sight, thought, or feeling of needles or needle-like objects. The primary symptom of vasovagal fear is vasovagal syncope, or fainting due to a decrease of blood pressure.
Many people who suffer from fainting during needle procedures report no conscious fear of the needle procedure itself, but a great fear of the vasovagal syncope reaction. A study in the medical journal Circulation concluded that in many patients with this condition (as well as patients with the broader range of blood/injury phobias), an initial episode of vasovagal syncope during a needle procedure may be the primary cause of needle phobia rather than any basic fear of needles. These findings reverse the more commonly held beliefs about the cause-and-effect pattern of needle phobics with vasovagal syncope.
The physiological changes associated with this type of phobia also include feeling faint, sweating, nausea, pallor, tinnitus, panic attacks, and initially high blood pressure and heart rate followed by a plunge in both at the moment of injection.
Although most phobias are dangerous to some degree, needle phobia is one of the few that actually kill. In cases of severe phobia, the drop in blood pressure caused by the vasovagal shock reflex may cause death. In Hamilton's 1995 review article on needle phobia, he was able to document 23 deaths as a direct result of vasovagal shock during a needle procedure.
The best treatment strategy for this type of needle phobia has historically been desensitization or the progressive exposure of the patient to gradually more frightening stimuli, allowing them to become desensitized to the stimulus that triggers the phobic response. In recent years, a technique known as "applied tension" has become increasingly accepted as an often effective means for maintaining blood pressure to avoid the unpleasant, and sometimes dangerous, aspects of the vasovagal reaction.
Associative fear of needles is the second most common type, affecting 30% of needle phobics. This type is the classic specific phobia in which a traumatic event such as an extremely painful medical procedure or witnessing a family member or friend undergo such, causes the patient to associate all procedures involving needles with the original negative experience.
This form of fear of needles causes symptoms that are primarily psychological in nature, such as extreme unexplained anxiety, insomnia, preoccupation with the coming procedure and panic attacks. Effective treatments include cognitive therapy, hypnosis, and/or the administration of anti-anxiety medication.
Resistive fear of needles occurs when the underlying fear involves not simply needles or injections but also being controlled or restrained. It typically stems from repressive upbringing or poor handling of prior needle procedures i.e. with forced physical or emotional restraint.
This form of needle phobia affects around 20% of those afflicted. Symptoms include combativeness, high heart rate coupled with extremely high blood pressure, violent resistance, avoidance and flight. The suggested treatment is psychotherapy, teaching the patient self-injection techniques or finding a trusted health care provider.
Hyperalgesic fear of needles is another form that does not have as much to do with fear of the actual needle. Patients with this form have an inherited hypersensitivity to pain, or hyperalgesia. To them, the pain of an injection is unbearably great and many cannot understand how anyone can tolerate such procedures.
This form of fear of needles affects around 10% of needle phobes. The symptoms include extreme explained anxiety, and elevated blood pressure and heart rate at the immediate point of needle penetration or seconds before. The recommended forms of treatment include some form of anesthesia, either topical or general.
Whilst witnessing procedures involving needles it is possible for the phobic present to suffer the symptoms of a needle phobic attack without actually being injected. Prompted by the sight of the injection the phobic may exhibit the normal symptoms of vasovagal syncope and fainting or collapse is common. While the cause of this is not known, it may be due to the phobic imagining the procedure being performed on themselves. Recent neuroscience research shows that feeling a pin prick sensation and watching someone else's hand get pricked by a pin activate the same part of the brain. 
Comorbidity and triggers
Fear of needles, especially in its more severe forms, is often comorbid with other phobias and psychological ailments; for example, iatrophobia, or an irrational fear of doctors, is often seen in needle phobic patients.
A needle phobic patient does not need to physically be in a doctor's office to experience panic attacks or anxiety brought on by needle phobia. There are many triggers in the outside world that can bring on an attack through association. Some of these are blood, injuries, the sight of the needle physically or on a screen, paper pins, syringes, examination rooms, white lab coats, dentists, nurses, the antiseptic smell associated with offices and hospitals, the sight of a person who physically resembles the patient's regular health care provider, or even reading about the fear.
The medical literature suggests a number of treatments that have been proven effective for specific cases of needle phobia, but provides very little guidance to predict which treatment may be effective for any specific case. The following are some of the treatments that have been shown to be effective in some specific cases.
- Ethyl Chloride Spray (and other freezing agents). Easily administered, but provides only superficial pain control.
- Jet Injectors. Jet Injectors work by introducing substances into the body through a jet of high pressure gas as opposed to by a needle. Though these eliminate the needle, some people report that they cause more pain. Also, they are only helpful in a very limited number of situations involving needles i.e. insulin and some inoculations.
- Iontophoresis. Iontophoresis drives anesthetic through the skin by using an electric current. It provides effective anesthesia, but is generally unavailable to consumers on the commercial market and some regard it as inconvenient to use.
- EMLA. EMLA is a topical anesthetic cream that is a eutectic mixture of lidocaine and prilocaine. It is a prescription cream in the United States, and is available without prescription in some other countries. Although not as effective as iontophoresis, since EMLA does not penetrate as deeply as iontophoresis-driven anesthetics, EMLA provides a simpler application than iontophoresis. EMLA penetrates much more deeply than ordinary topical anesthetics, and it works adequately for many individuals.
- Ametop. Ametop gel  appears to be more effective than EMLA for eliminating pain during venepuncture.
- Lidocaine/tetracaine patch. A self-heating patch containing a eutectic mixture of lidocaine and tetracaine is available in several countries, and has been specifically approved by government agencies for use in needle procedures. The patch is sold under the trade name Synera in the United States and Rapydan in European Union. Each patch is packaged in an air-tight pouch. It begins to heat up slightly when the patch is removed from the packaging and exposed to the air. The patch requires 20 to 30 minutes to achieve full anesthetic effect. The Synera patch was approved by the United States Food and Drug Administration on 23 June 2005.
- Behavioral therapy. Effectiveness of this varies greatly depending on the person and the severity of the condition. There is some debate as to the effectiveness of behavioral treatments for specific phobias (like blood, injection, injury type phobias), though some data are available to support the efficacy of approaches like exposure therapy. Any therapy that endorses relaxation methods may be contraindicated for the treatment of fear of needles as this approach encourages a drop in blood pressure that only enhances the vasovagal reflex. In response to this, graded exposure approaches can include a coping component relying on applied tension as a way to prevent complications associated with the vasovagal response to specific blood, injury, injection type stimulus.
- Nitrous Oxide (Laughing Gas). This will provide sedation and reduce anxiety for the patient, along with some mild analgesic effects.
- Inhalation General Anesthesia. This will eliminate all pain and also all memory of any needle procedure. On the other hand, it is often regarded as a very extreme solution. It is not covered by insurance in most cases, and most physicians will not order it. It can be risky and expensive and may require a hospital stay.
- Benzodiazepines, such as diazepam (Valium) or lorazepam, may help alleviate the anxiety of needle phobics, according to Dr. James Hamilton. These medications have an onset of action within 5 to 15 minutes from ingestion. A relatively large oral dose may be necessary.
- James G. Hamilton (August 1995). "Needle Phobia - A Neglected Diagnosis". Journal of Family Practice. 41 (2): 169–175 REVIEW. PMID 7636457.
- "Oxford Textbook of Psychopathology" by Theodore Millon, Paul H. Blaney, Roger D. Davis (1999) ISBN 0-19-510307-6, p. 82
- Ellinwood, Everett H.; Hamilton, James G. (April 1991). "Case report of a needle phobia". Journal of Family Practice. 32 (4): 420–422. PMID 2010743.
- Rolf R. Diehl (April 2005). "Vasovagal syncope and Darwinian fitness". Clinical Autonomic Research. 15 (2): 126–129. doi:10.1007/s10286-005-0244-0. PMID 15834770.
- Bracha, H. (2006). "Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30 (5): 827–853. doi:10.1016/j.pnpbp.2006.01.008. PMID 16563589.
- Accurso, V.; et al. (August 2001). "Predisposition to Vasovagal Syncope in Subjects With Blood/Injury Phobia". Circulation. 104 (8): 903–907. doi:10.1161/hc3301.094910. PMID 11514377. 
- Ost, L.G.; et al. (1991). "Applied tension, exposure in vivo, and tension-only in the treatment of blood phobia". Behaviour Research and Therapy. 29 (6): 561–574. doi:10.1016/0005-7967(91)90006-O. PMID 1684704.
- Ditto, B.; et al. (2009). "Physiological correlates of applied tension may contribute to reduced fainting during medical procedures". Annals of Behavioral Medicine. 37 (3): 306–314. doi:10.1007/s12160-009-9114-7. PMID 19730965.
- Ayala, E.S.; et al. (2009). "Treatments for blood-injury-injection phobia: a critical review of current evidence". Journal of Psychiatric Research. 43 (15): 1235–1242 REVIEW. doi:10.1016/j.jpsychires.2009.04.008. PMID 19464700.
- Morrison, I.; et al. (June 2004). "Vicarious responses to pain in anterior cingulate cortex: is empathy a multisensory issue?". Cognitive Affective and Behavioral Neuroscience. 4 (2): 270–278. doi:10.3758/CABN.4.2.270. PMID 15460933. 
- Hogan, M.E.; et al. (10 February 2010). "A systematic review of measures for reducing injection pain during adult immunization". Vaccine. 28 (6): 1514–1521. doi:10.1016/j.vaccine.2009.11.065. PMID 20003927.
- Schramm-Baxter, J.R.; Mitragotri, S. (2004). "Investigations of needle-free jet injections". Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 5: 3543–3546. doi:10.1109/IEMBS.2004.1403996. ISBN 0-7803-8439-3. PMID 17271055.
- Greenbaum, S.S.; Bernstein, E.F. (September 1994). "Comparison of iontophoresis of lidocaine with a eutectic mixture of lidocaine and prilocaine (EMLA) for topically administered local anesthesia". Journal of Dermaologic Surgery and Oncology. 20 (9): 579–583. PMID 8089357.
- Smith & Nephew. Ametop Gel information.
- Arrowsmith, J.; Campbell, C. (2000). "A comparison of local anaesthetics for venepuncture". Archives of Disease in Childhood. 82 (4): 309–310. doi:10.1136/adc.82.4.309. PMC 1718269. PMID 10735838.
- Sawyer, James; et al. (February 2009). "Heated lidocaine/tetracaine patch compared with lidocaine/prilocaine cream for topical anaesthesia before vascular access". British Journal of Anaesthesia. 102 (2): 210–215. doi:10.1093/bja/aen364. PMID 19151049. Retrieved 2010-11-27. 
- Stewart, J.E. (May 1994). "Diagnosis and treatment of phobia". Professional Nurse. 9 (8): 549–552. PMID 8008769.
- Shabani, D.B.; Fisher, W.W. (Winter 2006). Woods, Douglas W., ed. "Stimulus Fading and Differential Reinforcement for the Treatment of Needle Phobia in a Youth with Autism". Journal of Applied Behavior Analysis. 39 (4): 449–552. doi:10.1901/jaba.2006.30-05. PMC 1702338. PMID 17236343. 
- Dental Fear Central. Blood-injury-injection phobia, fainting, and applied tension.