|Full name||Federico Javier Santander Mereles|
|Date of birth||4 June 1991|
|Place of birth||San Lorenzo, Paraguay|
|Height||1.87 m (6 ft 2 in)|
|2010–2011||→ Toulouse (loan)||23||(5)|
|2012–2013||→ Tigre (loan)||18||(1)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 9 April 2017.
‡ National team caps and goals correct as of 23 March 2017
Santander ranked number 3 in a list of the most expensive players in Paraguayan football for 2015 published by Diario Extra.
Santander started in the youth divisions of Guaraní where he excelled and was part of the under-20 squad that won the international friendly championship held in Valencia, Spain. After winning the U20 tournament with Guaraní he attracted the interest of several clubs and had a trial with A.C. Milan. In 2008, at the age of 16, he made his debut with the senior squad of Guaraní by scoring a goal in the 5–2 win against Tacuary. On 31 August 2010, He sign to the French Toulouse FC.
In July 2012, Santander joined Argentine Primera División side Tigre on a one-year loan deal despite that Guaraní had intentions to bring him back to Paraguay. He was handed the number #24 shirt for the 2012–13 season and debuted in a 2–1 home defeat against Estudiantes de La Plata on 6 August 2012.
On 14 June 2015, Santander signed a five-year contract with the Danish Superliga team F.C. Copenhagen. He joined the club after completing Copa Libertadores with Guaraní. He made his league debut on 2 August 2015 against SønderjyskE making two assist, assisting Thomas Delaney and William Kvist. Three days later, he scored his first goal in a 2–3 defeat against FK Jablonec as Copenhagen failed to qualify for the UEFA Europa League group stage. On 16 May 2016, he netted twice to give his club a 2–0 win against Nordsjaelland which crowned Copenhagen league champions. In his first season in Copenhagen he became the third highest goalscorer with 14 goals and 4 assists.
|1.||4 June 2011||Estadio Ramón Tahuichi Aguilera, Santa Cruz de la Sierra, Bolivia||Bolivia||0–2||0–2||Friendly|
- "Los jugadores más caros del fútbol paraguayo". Diario Extra (in Spanish). 19 July 2015. Retrieved 18 August 2016.
- Guaraní se jacta de ser la mejor conexión para el fútbol europeo - Diario La Nación
- Guaraní fulminó con goles a Tacuary y eleva su cotización - Diario La Nación
- "Basile tendrá en el banco los goles de Santander". Diario Popular (in Spanish). 10 February 2012. Retrieved 18 August 2016.
- "Federico Santander va al Racing de Avellaneda" [Federico Santander goes to Racing de Avellaneda]. Paraguay.com (in Spanish). 3 February 2012. Retrieved 18 August 2016.
- "Tigre apuesta por los goles del paraguayo Santander" [Tigre bets on goals from Paraguayan Santander]. La Nación (in Spanish). 19 July 2012. Retrieved 18 August 2016.
- "Tigre: firmó el paraguayo Santander" [Tigre: signed Paraguayan Santander]. ESPN Deportes (in Spanish). 20 July 2012. Retrieved 18 August 2016.
- "F.C. København køber Federico Santander". F.C. København (in Danish). 14 June 2015. Retrieved 18 August 2016.
- "Federico Santander va al Copenhague de Dinamarca". La Nación (in Spanish). 11 June 2015. Retrieved 18 August 2016.
- "FCK fliegt gegen Jablonec raus". Nordschleswiger (in German). 6 August 2015. Retrieved 18 August 2016.
- O'Connor, Phillip (16 May 2016). "Santander fires FC Copenhagen to Danish title". Reuters. Retrieved 18 August 2016.
- Vou, Andreas. "Late Copenhagen strike breaks APOEL hearts". Cyprus Mail. Retrieved 25 August 2016.
- "Santander es Champions". Diario ABC Color (in Spanish). 24 August 2016. Retrieved 25 August 2016.
- "Champions: Federico Santander da clasificación al Copenhague". D10.com.py (in Spanish). 24 August 2016. Retrieved 25 August 2016.