The women's épée was one of ten fencing events on the fencing at the 2000 Summer Olympics programme. It was the second appearance of the event. The competition was held on 17 September 2000. 39 fencers from 22 nations competed.
The field of 39 fencers from 22 nations competed in a single-elimination tournament to determine the medal winners. Semifinal losers proceeded to a bronze medal match.