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Clinical data
Trade namesLomexin, Gynoxin
AHFS/Drugs.comInternational Drug Names
Routes of
Topical (ovule, spray, cream)
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: Not approved
  • In general: ℞ (Prescription only)
  • 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass455.40 g·mol−1
3D model (JSmol)
  • c1ccc(cc1)Sc2ccc(cc2)COC(Cn3ccnc3)c4ccc(cc4Cl)Cl
  • InChI=1S/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2 ☒N
 ☒NcheckY (what is this?)  (verify)

Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

Uses and administration[edit]

A 200 mg pessary is inserted into the vagina at bedtime for 3 nights or a 600 mg pessary is inserted once only at bedtime. Fenticonazole Nitrate vaginal capsule is not greasy, does not soil and can easily be removed with water.[1] Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

Pregnancy and lactation[edit]

Oran administration of Fenticonazole in rats has been reported to produce prolonged gestation and embryotoxic effects after doses above 40mg/kg/day. Fenticonazole does not interfere with the function of male and female gonads and does not modify the first phases of reproduction. Fenticonazole has shown no teratogenic effects in rats and rabbits. Fenticonazole or its metabolites cross the placental barrier in pregnant rats and rabbits after vaginal application and are excreted in milk of lactating rats. Since there is no experience of use during pregnancy or lactation, Fenticonazole Nitrate vaginal capsules should not be used unless the physician considers if essential to the welfare of the patient.[1]

Adverse effects[edit]

Burning and itching have been reported after the application of fenticonazole nitrate.

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.


  1. ^ a b Stewart M (20 October 2020). Dajani S (ed.). "Fenticonazole for vaginal thrush". Patient. Egton Medical Information Systems Limited.

Further reading[edit]

  • Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.). Whitehouse Station, NJ: Merck. ISBN 978-0-911910-12-4. 4047.