He was the personal physician of Pope Innocent VIII. He was then Lector of the Audience of lettere Contraddette. He was an Apostolic Secretary under Pope Alexander VI and Pope Julius II. He then joined the Apostolic Camera, serving as its dean, president, and treasurer in 1513.
He resigned the administration of the see of Molfetta to his nephew Giacomo Ponzetta on July 12, 1518. He participated in the papal conclaave of 1521-22 that elected Pope Adrian VI. On December 22, 1522, he was transferred to the see of Grosseto, occupying this see until resigning on February 25, 1527. He participated in the papal conclave of 1523 that elected Pope Clement VII. He lost all of his wealth during the Bourbon sack of Rome in 1526.