Ferredoxin—nitrite reductase

From Wikipedia, the free encyclopedia
  (Redirected from Ferredoxin-nitrite reductase)
Jump to: navigation, search
ferredoxin—nitrite reductase
EC number
CAS number 37256-44-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a ferredoxin—nitrite reductase (EC is an enzyme that catalyzes the chemical reaction

NH3 + 2 H2O + 6 oxidized ferredoxin nitrite + 6 reduced ferredoxin + 7 H+

The 3 substrates of this enzyme are NH3, H2O, and oxidized ferredoxin, whereas its 3 products are nitrite, reduced ferredoxin, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is ammonia:ferredoxin oxidoreductase. This enzyme participates in nitrogen metabolism and nitrogen assimilation. It has 3 cofactors: iron, Siroheme, and Iron-sulfur.

This enzyme can use many different isoforms of ferredoxin. In photosynthesizing tissues, it uses ferredoxin that is reduced by PSI and in the root it uses a form of ferredoxin (FdIII) that has a less negative midpoint potential and can be reduced easily by NADPH.[1]

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1ZJ8, 1ZJ9, and 2AKJ.


  1. ^ Hanke, G. T.; Kimata-Ariga, Y.; Taniguchi, I.; Hase, T. (2004). "A Post Genomic Characterization of Arabidopsis Ferredoxins". Plant Physiology. 134 (1): 255–264. doi:10.1104/pp.103.032755. PMC 316305Freely accessible. PMID 14684843.