Ferredoxin hydrogenase

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ferredoxin hydrogenase
Identifiers
EC number 1.12.7.2
CAS number 9080-02-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a ferredoxin hydrogenase (EC 1.12.7.2) is an enzyme that catalyzes the chemical reaction

H2 + 2 oxidized ferredoxin 2 reduced ferredoxin + 2 H+

Thus, the two substrates of this enzyme are H2 and oxidized ferredoxin, whereas its two products are reduced ferredoxin and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is hydrogen:ferredoxin oxidoreductase. Other names in common use include H2 oxidizing hydrogenase, H2 producing hydrogenase [ambiguous], bidirectional hydrogenase, hydrogen-lyase [ambiguous], hydrogenase (ferredoxin), hydrogenase I, hydrogenase II, hydrogenlyase [ambiguous], and uptake hydrogenase [ambiguous]. This enzyme participates in glyoxylate and dicarboxylate metabolism and methane metabolism. It has 3 cofactors: iron, Sulfur, and Nickel.

References[edit]

  • Shug AL, Wilson PW, Green DE, Mahler HR (1954). "The role of molybdenum and flavin in hydrogenase". J. Am. Chem. Soc. 76 (12): 3355–3356. doi:10.1021/ja01641a090. 
  • Tagawa K, Arnon DI. "Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas". N. Lond. Nature: 537–543. 
  • Valentine RC, Mortenson LE, Carnahan JE (1963). "The hydrogenase system of Clostridium pasteurianum". J. Biol. Chem. 238: 1141–1144. 
  • Zumft WG, Mortenson LE (1975). "The nitrogen-fixing complex of bacteria". Biochim. Biophys. Acta. 416 (1): 1–52. PMID 164247. doi:10.1016/0304-4173(75)90012-9. 
  • Adams MW (1990). "The structure and mechanism of iron-hydrogenases". Biochim. Biophys. Acta. 1020 (2): 115–45. PMID 2173950. doi:10.1016/0005-2728(90)90044-5. 
  • Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC (1998). "X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution". Science. 282 (5395): 1853–8. PMID 9836629. doi:10.1126/science.282.5395.1853.