Fibrin ring granuloma

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A fibrin ring granuloma, also known as doughnut granuloma, is a histopathological finding that is characteristic of Q fever.[1] On hematoxylin-eosin staining, the fibrin ring granuloma consists of a central lipid vacuole (usually washed-out during fixing and staining, leaving only an empty hole) surrounded by a dense red fibrin ring and epithelioid macrophages. Fibrin ring granulomas may also be seen in Hodgkin's disease and infectious mononucleosis.[2][3]

See also[edit]


  1. ^ Rosen, MD, Yale. "Fibrin Ring Granulomas". Atlas of Granulomatous Diseases. Yale Rosen, MD. Retrieved 2012-09-18. 
  2. ^ Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W (2001). "Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature". Acta Clin Belg. 56 (6): 341–8. doi:10.1179/acb.2001.051. PMID 11881318. 
  3. ^ de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq-Giraudon B (July 1993). "Hepatic fibrin-ring granulomas in giant cell arteritis". Gastroenterology. 105 (1): 272–3. PMID 8514044.