Fibrolase

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Fibrolase
Identifiers
EC number 3.4.24.72
CAS number 116036-70-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in Aalpha-chain of fibrinogen

This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).

References[edit]

  1. ^ Retzios, A.D.; Markland, F.S. Jr. (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thromb. Res. 52: 541–552. PMID 3232124. doi:10.1016/0049-3848(88)90127-2. 
  2. ^ Guan, A.L.; Retzios, A.D.; Henderson, G.N.; Markland, F.S. Jr. (1991). "Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)". Arch. Biochem. Biophys. 289: 197–207. PMID 1898066. doi:10.1016/0003-9861(91)90462-r. 
  3. ^ Randolph, A.; Chamberlain, S.H.; Chu, H.L.C.; Retzios, A.D.; Markland, F.S. (1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom". Protein Sci. 1: 590–600. PMC 2142229Freely accessible. PMID 1304358. doi:10.1002/pro.5560010505. 
  4. ^ Loayza, S.L.; Trikha, M.; Markland, F.S.; Riquelme, P.; Kuo, J. (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". J. Chromatogr. B Biomed. Appl. 662: 227–243. PMID 7719479. doi:10.1016/0378-4347(94)00202-9. 
  5. ^ Retzios, A.D.; Markland, F.S. (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin". Thromb. Res. 74: 355–367. PMID 8085237. doi:10.1016/0049-3848(94)90151-1. 

External links[edit]