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CAS number 116036-70-5
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Fibrolase (EC, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in Aalpha-chain of fibrinogen

This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).


  1. ^ Retzios, A.D.; Markland, F.S. Jr. (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thromb. Res. 52: 541–552. PMID 3232124. doi:10.1016/0049-3848(88)90127-2. 
  2. ^ Guan, A.L.; Retzios, A.D.; Henderson, G.N.; Markland, F.S. Jr. (1991). "Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)". Arch. Biochem. Biophys. 289: 197–207. PMID 1898066. doi:10.1016/0003-9861(91)90462-r. 
  3. ^ Randolph, A.; Chamberlain, S.H.; Chu, H.L.C.; Retzios, A.D.; Markland, F.S. (1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom". Protein Sci. 1: 590–600. PMC 2142229Freely accessible. PMID 1304358. doi:10.1002/pro.5560010505. 
  4. ^ Loayza, S.L.; Trikha, M.; Markland, F.S.; Riquelme, P.; Kuo, J. (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". J. Chromatogr. B Biomed. Appl. 662: 227–243. PMID 7719479. doi:10.1016/0378-4347(94)00202-9. 
  5. ^ Retzios, A.D.; Markland, F.S. (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin". Thromb. Res. 74: 355–367. PMID 8085237. doi:10.1016/0049-3848(94)90151-1. 

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