Fifth Amendment may refer to:
- Fifth Amendment to the United States Constitution, part of the Bill of Rights, which protects against the abuse of government authority in legal proceedings
- Fifth Amendment of the Constitution of Ireland, a referendum related to the Roman Catholic Church and other religious denominations
- Australian referendum, 1967 (Aboriginals), the fifth amendment to the Constitution of Australia, regarding the constitutional position of Indigenous Australians
- Fifth Amendment of the Constitution of South Africa, which made technical changes relating to the election of the National Assembly and the structure of the Financial and Fiscal Commission
- Fifth Amendment to the Constitution of Pakistan
- Fifth Amendment, album by The Vibrators
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