|Chemical and physical data|
|Molar mass||292.33 g/mol g·mol−1|
|3D model (JSmol)|
Filaminast (code name WAY-PDA 641) was a drug candidate developed by Wyeth-Ayerst.:Table 2 It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts.:668, 678 It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.:678
- Filaminist entry at Pubchem
- Halpin DM. ABCD of the phosphodiesterase family: interaction and differential activity in COPD. Int J Chron Obstruct Pulmon Dis. 2008;3(4):543-61. PMID 19281073 PMC 2650605
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