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File:HLA-DM transport and functions from the ER to the cell surface of an APC.jpg

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Summary[edit]

Description
English: HLA-DM is synthesized in the endoplasmic reticulum (ER) of antigen presenting cells (APCs), and transported in endosomes while binding to HLA-DO. The HLA-DM containing endosome fuses with an MHC class II containing endosome, which then subsequently fuses with an antigen-containgin endosome. Once in the presence of antigen, HLA-DM associates with MHC class II and releases CLIP form the peptide binding groove. HLA-DO degrades, and HLA-DM facilitates peptide exchange to ensure high affinity binding between the MHC class II and it's peptide. The late endosome then fuses with the plasma membrane to present MHC class II + peptide on its surface. This can be recognized by other immune cells and initiate a response.
Date
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Author Immcarle51

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Date/TimeThumbnailDimensionsUserComment
current01:56, 6 March 2018Thumbnail for version as of 01:56, 6 March 20181,119 × 821 (82 KB)Immcarle51Cross-wiki upload from en.wikipedia.org
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