This is a file from the Wikimedia Commons

File:Steroidogenesis.svg

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Original file(SVG file, nominally 1,245 × 1,105 pixels, file size: 198 KB)

Render this image in .

Summary

Description
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は(コレステロールから)プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ(生合成の過程で)オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Date 28 March 2009
Source Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author

David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

In external use, this diagram may be cited as:

Other versions

edit

Translations

SVG developmentW3C grn.svg The source code of this SVG is valid.Inkscape-yes.svg This diagram was created with Inkscape, or with something else.Add Language.svg   This SVG diagram uses embedded text that can be easily translated using a text editor.

Wikipedia

Cscr-featured.svg This is a featured picture on the English language Wikipedia (Featured pictures) and is considered one of the finest images. See its nomination here.

If you think this file should be featured on Wikimedia Commons as well, feel free to nominate it.
If you have an image of similar quality that can be published under a suitable copyright license, be sure to upload it, tag it, and nominate it.


azərbaycanca  Bahasa Indonesia  Bahasa Melayu  català  čeština  dansk  Cymraeg  Deutsch  eesti  español  English  Esperanto  euskara  français  Gagauz  galego  hrvatski  italiano  lietuvių  Lëtzebuergesch  magyar  Malti  Nederlands  norsk  norsk bokmål  norsk nynorsk  Plattdüütsch  polski  português  português do Brasil  română  Schweizer Hochdeutsch  sicilianu  slovenščina  suomi  svenska  Tagalog  Tiếng Việt  Türkçe  Yorùbá  Zazaki  Ελληνικά  беларуская (тарашкевіца)‎  беларуская (тарашкевіца)‎  қазақша  қазақша (кирил)‎  македонски  нохчийн  русский  српски / srpski  татарча/tatarça  українська  ქართული  հայերեն  मराठी  हिन्दी  অসমীয়া  বাংলা  தமிழ்  മലയാളം  ไทย  조선말  한국어  日本語  中文(简体)‎  中文(繁體)‎  עברית  العربية  فارسی  کوردی  +/−

Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.

Licensing

GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.
w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
This licensing tag was added to this file as part of the GFDL licensing update.

Captions

A schematic diagram showing the chemicals, enzymes, and locations of the human steroidogenesis pathways.

Items portrayed in this file

depicts

28 March 2009

File history

Click on a date/time to view the file as it appeared at that time.

(newest | oldest) View (newer 10 | ) (10 | 20 | 50 | 100 | 250 | 500)
Date/TimeThumbnailDimensionsUserComment
current15:58, 8 April 2020Thumbnail for version as of 15:58, 8 April 20201,245 × 1,105 (198 KB)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:54, 8 April 2020Thumbnail for version as of 15:54, 8 April 20201,245 × 1,105 (187 KB)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:12, 13 March 2013Thumbnail for version as of 15:12, 13 March 20131,245 × 1,105 (133 KB)SlashmeRemoved arrow from Corticosterone to Cortisol via CYP17A1 (see http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
16:15, 9 July 2012Thumbnail for version as of 16:15, 9 July 20121,245 × 1,105 (133 KB)Mikael HäggströmAddition and correction of stereochemistries at positions 11 and 17.
04:24, 9 July 2012Thumbnail for version as of 04:24, 9 July 20121,245 × 1,105 (127 KB)Mikael HäggströmAdded stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
05:15, 13 December 2011Thumbnail for version as of 05:15, 13 December 20111,245 × 1,105 (114 KB)SlashmeAlign some text and arrows for neatness' sake.
04:56, 13 December 2011Thumbnail for version as of 04:56, 13 December 20111,245 × 1,105 (114 KB)SlashmeFixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
12:58, 8 May 2010Thumbnail for version as of 12:58, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggströmminor move of 5-a-reductase
12:56, 8 May 2010Thumbnail for version as of 12:56, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggströmminor renaming of 3-beta-HSD
06:46, 24 April 2010Thumbnail for version as of 06:46, 24 April 20101,245 × 1,105 (114 KB)Mikael HäggströmMoved name out of molecular structure
(newest | oldest) View (newer 10 | ) (10 | 20 | 50 | 100 | 250 | 500)
The following pages on the English Wikipedia use this file (pages on other projects are not listed):

Global file usage

Metadata