Flavokavain A

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Flavokavain A
Flavokavain A.svg
Names
IUPAC name
(E)-3-(4-methoxyphenyl)-1-(2,4-bismethoxy-6-hydroxyphenyl)propenone
Other names
2'-hydroxy-4,4',6'-trimethoxychalcone
Flavokawain A
Identifiers
37951-13-6 YesY
2224776
Jmol 3D model Interactive image
PubChem 5355469
Properties
C18H18O5
Molar mass 314.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Flavokavain A is a flavokavain found in the kava plant.[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.[2]

See also[edit]

References[edit]

  1. ^ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162. 
  2. ^ Zi X, Simoneau AR (April 2005). "Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.". Cancer Research. 65 (8): 3479–86. doi:10.1158/0008-5472.CAN-04-3803. PMID 15833884. 

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