Temporal range: Middle Ordovician to Early Silurian 
Flexicalymene is a genus of trilobites of the order Phacopida, suborder Calymenina. They are found abundantly in North America. Flexicalymene specimens can be mistaken for Calymene, Gravicalymene, Diacalymene and a few other Calymenina genera. They are used as an index fossil in the Ordovician. Ohio and North America are particularly known for being rich with Flexicalymene fossils. Species include F. meeki and F. retrorsa (Ohio, Kentucky and Indiana), F. granulosa (Ohio, Kentucky and Quebec), F. senaria (Quebec) and F. croneisi (Ontario).
Flexicalymene species on display at State Museum of Pennsylvania. Specimen is approximately 3 cm long
- "†Flexicalymene Shirley 1936 (trilobite)". Paleobiology Database. Retrieved 21 August 2011.
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