Flubendazole

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Flubendazole
Flubendazole.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code P02CA05 (WHO) QP52AC12 (WHO)
Identifiers
CAS Number 31430-15-6 YesY
PubChem (CID) 35802
DrugBank DB08974 N
ChemSpider 32932 N
UNII R8M46911LR N
KEGG D04200 YesY
ChEBI CHEBI:77095 N
ChEMBL CHEMBL145946 N
ECHA InfoCard 100.046.007
Chemical and physical data
Formula C16H12FN3O3
Molar mass 313.28 g/mol
3D model (Jmol) Interactive image
Melting point 260 °C (500 °F)
 NYesY (what is this?)  (verify)

Flubendazole is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.[1]

It is also available for human use to treat worm infections. It is available OTC (without prescription) in Europe.

Since 2000, Flubendazole-treated grit has increasingly been laid out on a landscape-scale across many UK grouse-shooting moors by gamekeepers in an attempt to reduce the impact on bird numbers from strongyle worm. Evidence of high worm burden is required before a veterinarian can dispense and sell the product, known as 'medicated grit'.[2] However, there has been increasing concern about contaminants entering the ground waters running off from moorlands, as well as from its use in farming environments and its presence in manure. Researchers are starting to gather research evidence in order to inform policy development on the presence of this and other veterinary medicines in the wider environment.[3][4]

See also[edit]

References[edit]

  1. ^ US Patent 5824336 - Chewable flubendazole tablets for companion animals
  2. ^ "Best practice use of medicated grit". Game and Wildlife Conservation Trust. Retrieved 27 September 2016. 
  3. ^ Kay, Dr. Paul. "Analysis, occurrence and effects of flubendazole in moorland river catchments". www.nercdtp.leeds.ac.uk. Leeds York NERC Doctoral Training Partnership (DTP). Retrieved 11 January 2017. 
  4. ^ Kreuzig, Robert; Blümlein, Katharina; Höltge, Sibylla (November 2007). "Fate of the Benzimidazole Antiparasitics Flubendazole and Fenbendazole in Manure and Manured Soils". CLEAN - Soil Air Water. 35 (5): 488–494. doi:10.1002/clen.200720023. Retrieved 11 January 2017.