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Fluffy may refer to:
- Fluffy, stand-up comedian Gabriel Iglesias
- Fluffy (UAV), an unmanned aerial vehicle
- Fluffy transcription factor, a gene of the mold Neurospora crassa
- Fluffy (footwear), a form of fashion accessory.
Comics and literature
- Fluffy, a fictional cat character in the Disney comics series Darkwing Duck
- Fluffy (comics), a 2003 graphic novel by Simone Lia
- Fluffy (Harry Potter), a giant three-headed dog in the novel Harry Potter and the Sorcerer's Stone
Film and television
- Fluffy (1965 film), a 1965 film starring Tony Randall and Shirley Jones
- Fluffy, a 2003 short film starring Fred Ewanuick
- Fluffy, a fictional pet elephant belonging to the character Oscar the Grouch on the TV series Sesame Street
- Fluffy, a fictional pet pig belonging to the character Eric Cartman on the TV series South Park
- Fluffy, a one-shot character in the episode, "Puppy Love" on the Pajanimals
- F.L.U.F.F.I., a fictional robot ape belonging to the Bennett family on the TV series Bionic Six
- Fluffy, a 1990s band associated with the band Breakfast with Amy
- Fluffy (band), a 1990s UK punk band
- "Fluffy", a 2013 single by Wolf Alice
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