|Trade names||Sibelium, others|
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|Elimination half-life||5–15 hrs (single dose)|
18–19 days (multiple doses)
|Excretion||Feces, <1% urine|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||404.495 g/mol g·mol−1|
|3D model (JSmol)|
|Melting point||251.5 °C (484.7 °F) (dihydrochloride)|
Flunarizine, sold under the brand name Sibelium among others, is a drug classified as a calcium antagonist which is used for various indications. It is not available by prescription in the United States or Japan. The drug was discovered at Janssen Pharmaceutica (R14950) in 1968.
Flunarizine is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children.
Flunarizine is contraindicated in patients with depression, in the acute phase of a stroke, and in patients with extrapyramidal symptoms or Parkinson's disease. It is also contraindicated in hypotension, heart failure and arrhythmia.
Mechanism of action
Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels. It has been theorised that it may act not by inhibiting calcium entry into cells, but rather by an intracellular mechanism such as antagonising calmodulin, a calcium binding protein.
Flunarizine is well absorbed (>80%) from the gut and reaches maximal blood plasma concentrations after two to four hours, with more than 99% of the substance bound to plasma proteins. It readily passes the blood–brain barrier. When given daily, a steady state is reached after five to eight weeks. Concentrations in the brain are about ten times higher than in the plasma.
The substance is metabolised in the liver, mainly by the enzyme CYP2D6. At least 15 different metabolites are described, including (in animals) N-desalkyl and hydroxy derivatives and glucuronides. Less than 1% is excreted in unchanged form, and the main excretion path is via bile and faeces. Elimination half life varies widely between individuals and is about 5 to 15 hours after a single dose, and 18 to 19 days on average when given daily.
Flunarizine may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP). Both these conditions arise from specific mutations in the ATP1A3 gene.
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- Sapaly, Delphine; Dos Santos, Matthieu; Delers, Perrine; Biondi, Olivier; Quérol, Gwendoline; Houdebine, Léo; Khoobarry, Kevinee; Girardet, François; Burlet, Philippe; Armand, Anne-Sophie; Chanoine, Christophe; Bureau, Jean-François; Charbonnier, Frédéric; Lefebvre, Suzie (2018). "Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy". Scientific Reports. 8. doi:10.1038/s41598-018-20219-1. PMC 5794986.
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