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Fluvalinat Structural Formula V3.svg
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Molar mass502.913 g/mol g·mol−1
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Fluvalinate is a synthetic pyrethroid chemical compound contained as an active agent in the products Apistan, Klartan, and Minadox, that is an acaricide (specifically, a miticide), commonly used to control Varroa mites in honey bee colonies,[citation needed] infestations that constitute a significant disease of such insects.

Fluvalinate is a stable, nonvolatile,[1] viscous, heavy oil (technical) soluble in organic solvents.[2] Although the compound may be found in drones, a study has found honey samples virtually absent of fluvalinate, on account of its affinity to beeswax.[3][better source needed]


Fluvalinate is synthesized from racemic valine [(RS)-valine], the synthesis is not diastereoselective. Thus, fluvinate is a mixture of four stereoisomers, each about 25 %.[4]

Fluvalinate stereoisomers

Tau-fluvalinate (τ-fluvalinate) is the trivial name for (2R)-fluvalinate. The C atom in the valinate structure is in (R)-absolute configuration, while the second chiral atom is a mixture of (R)- and (S)-configurations:[2]

τ-Fluvalinate diastereomers

See also[edit]


  1. ^ "tau-fluvalinate", Pesticide Properties DataBase, University of Hertfordshire, retrieved June 24, 2017
  2. ^ a b "Tau-fluvalinate", PubChem. The Open Chemistry Database, National Institutes of Health, retrieved June 24, 2017
  3. ^ MAF Biosecurity New Zealand (2001). "A Review of Treatment Options for Control of Varroa Mite in New Zealand [HortResearch Client Report No. 2001/249]" (PDF). Retrieved 28 August 2016. This report was commissioned by MAF to aid in internal decision making only. This report in no way constitutes MAF's advice to beekeepers and is useful only as background information. Cite journal requires |journal= (help)[better source needed]
  4. ^ David M. Whitacre (2012), [[1], p. 125, at Google Books Reviews of environmental contamination and toxicology] Check |url= value (help) (in German), Springer, p. 125, ISBN 978-1-4614-3280-7

Further reading[edit]

External links[edit]