|Other names||Multifocal epithelial hyperplasia|
|Specialty||Oral and maxillofacial surgery|
Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity.:411 Can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32. It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies present. It was first identified in the Aboriginal population of North America.
- Tenore, G.; Palaia, G.; Del Vecchio, A.; Galanakis, A.; Romeo, U. (2013-10-24). "Focal epithelial hyperplasia (Heck's disease)". Annali di Stomatologia. 4 (Suppl 2): 43. ISSN 1824-0852. PMC 3860189. PMID 24353818.
- James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- James, William D.; Berger, Timothy; Elston, Dirk (2015). Andrews' Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences. p. 408. ISBN 9780323319690.
- Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children". Oral Surgery, Oral Medicine, Oral Pathology. 20 (2): 201–12. doi:10.1016/0030-4220(65)90192-1. PMID 14322615.
- Eversole, Lewis R. (2011). Clinical Outline of Oral Pathology: Diagnosis and Treatment. PMPH-USA. p. 285. ISBN 9781607950158. Retrieved 18 January 2018.
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