Folate-binding protein

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Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.[1]

It can be a marker for ovarian cancer.[2]

It can be measured to help in tumour classification to aid treatment. FBP is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.[3]

Alternative usage[edit]

FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.[4]