W. Ford Doolittle FRSC (born November 30, 1941 in Urbana, Illinois) is a biochemist. He is a member of the US National Academy of Sciences and a Fellow of the Royal Society of Canada and the Norwegian Academy of Science and Letters. He is also the winner of the 2014 Herzberg Medal of the Natural Sciences and Engineering Research Council of Canada.
Doolittle has made significant contributions to the study of cyanobacteria. He found evidence for the endosymbiont origins of chloroplasts, and developed a theoretical basis for the initial evolution of eukaryotes. He has shown the importance of horizontal gene transfer in prokaryotic evolution.
As of 2007[update], he has been Professor Emeritus at Dalhousie University in Halifax, Nova Scotia. He received his BA in Biochemical Sciences from Harvard University in 1963 and his PhD from Stanford University in 1967, under Charles Yanofsky. He went on to do postdoctoral fellowships with Sol Spiegelman and Norman R. Pace.
In 1981, Doolittle received some level of notoriety for his article in The CoEvolution Quarterly entitled "Is Nature Really Motherly?". This was a sharp rebuttal of J. E. Lovelock's formulation of the Gaia Theory. Doolittle's article is often cited by Lovelock's critics.
Because of his philosophical musings on the non-existence of an all-encompassing Tree of Life, Doolittle has occasionally been cited on Intelligent Design blogs. However, though Doolittle argues that a bifurcating tree is not an adequate metaphor for the evolution of life on earth, he is not a supporter of Intelligent Design. A single common ancestor and tree relating all of life on earth is not a necessary component of the theory of descent with modification, the essence of evolution.
Doolittle is currently involved in a debate about the proper use of function (biology) within evolutionary biology sparked by controversy over the results of the ENCODE consortium stating that 80% of the genome is "functional". He is a supporter of the concept of junk DNA.
In addition to his contributions to evolutionary biology, Doolittle is an artist who studied at NSCAD University, achieving a BA in photography.
- Owens, Brian (April 11, 2014). "W. Ford Doolittle". science.ca. GCS Research Society. Retrieved 20 August 2015.
- "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Science and Letters. Retrieved 7 October 2010.
- "Government of Canada Announces Top Award Winners in Natural Sciences and Engineering Research".
- Personal homepage at Dalhousie University
- W. Ford Doolittle (2004). "W. Ford Doolittle". Curr. Biol. 14 (5): R176–R177. doi:10.1016/j.cub.2004.02.010. PMID 15028226.
- Brown, James R.; Doolittle, W. Ford (1997). "Archaea and the prokaryote-to-eukaryote transition". Microbiology and Molecular Biology Reviews 61 (4): 456–502. PMC 232621. PMID 9409149.
- Doolittle, W. Ford (1999). "Phylogenetic Classification and the Universal Tree". Science 284 (5423): 2124–2129. doi:10.1126/science.284.5423.2124. PMID 10381871.
- Baldauf, S. L.; Roger, A. J.; Wenk-Siefert, I.; Doolittle, W. Ford (2000). "A Kingdom-Level Phylogeny of Eukaryotes Based on Combined Protein Data". Science 290 (5493): 972–977. doi:10.1126/science.290.5493.972. PMID 11062127.
- W.F.Doolittle on Google Scholar
- Taking an axe to the Tree of Life, an article describing Doolittle's views on updating Darwin's theory.
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