Foreign body granuloma

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Foreign body granuloma
Perforated IUD.jpg
Transvaginal ultrasonography showing a foreign body granuloma at right as a hypoechoic (dark) area around a perforated intrauterine device. The uterus is at left.
SpecialtyDermatology Edit this on Wikidata

The foreign body granuloma is a response of biological tissue to any foreign material in the tissue.[1] Tissue-encapsulation of an implant is part of this. An inflammation around a splinter is part of this, too.[2]

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.[3]


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  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1443. ISBN 978-1-4160-2999-1.
  2. ^ Biomaterials Science Second edition, Ratner et al. Pp. 296-304
  3. ^ Hilborn, Jöns; Bjursten, Lars M. (March 2007). "A new and evolving paradigm for biocompatibility". Journal of Tissue Engineering and Regenerative Medicine. 1 (2): 110–119. doi:10.1002/term.4. ISSN 1932-6254. PMID 18038399.

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