Formamidase

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formamidase
2e2l2.jpg
Formamidase hexamer, Helicobacter pylori
Identifiers
EC number3.5.1.49
CAS number9013-59-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a formamidase (EC 3.5.1.49) is an enzyme that catalyzes the chemical reaction

formamide + H2O formate + NH3

Thus, the two substrates of this enzyme are formamide and H2O, whereas its two products are formate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is formamide amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and nitrogen metabolism.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2DYU, 2DYV, 2E2K, and 2E2L.

References[edit]

  • Clarke PH (1970). "The aliphatic amidases of Pseudomonas aeruginosa". Adv. Microb. Physiol. Advances in Microbial Physiology. 4: 179–222. doi:10.1016/S0065-2911(08)60442-7. ISBN 978-0-12-027704-9.
  • Friedrich CG, Mitrenga G (1981). "Utilization of aliphatic amides and formation of two different amidases by Alcaligenes eutrophus". J. Gen. Microbiol. 125: 367–374. doi:10.1099/00221287-125-2-367.