Formate dehydrogenase (NADP+)

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formate dehydrogenase (NADP+)
Identifiers
EC number 1.2.1.43
CAS number 51377-43-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a formate dehydrogenase (NADP+) (EC 1.2.1.43) is an enzyme that catalyzes the chemical reaction

formate + NADP+ CO2 + NADPH

Thus, the two substrates of this enzyme are formate and NADP+, whereas its two products are CO2 and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GSD.

References[edit]