Formate dehydrogenase (cytochrome)

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
formate dehydrogenase (cytochrome)
Identifiers
EC number1.2.2.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a formate dehydrogenase (cytochrome) (EC 1.2.2.1) is an enzyme that catalyzes the chemical reaction

formate + 2 ferricytochrome b1 CO2 + 2 ferrocytochrome b1 + 2 H+

Thus, the two substrates of this enzyme are formate and ferricytochrome b1, whereas its 3 products are CO2, ferrocytochrome b1, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is formate:ferricytochrome-b1 oxidoreductase. Other names in common use include formate dehydrogenase, and formate:cytochrome b1 oxidoreductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References[edit]

  • Gale EF (June 1939). "Formic dehydrogenase of Bacterium coli: its inactivation by oxygen and its protection in the bacterial cell". The Biochemical Journal. 33 (6): 1012–27. doi:10.1042/bj0331012. PMC 1264479. PMID 16746983.