Formestane

Formestane
Clinical data
Trade names	Lentaron
Other names	4-Hydroxyandrost-4-ene-3,17-dione
AHFS/Drugs.com	International Drug Names
ATC code	L02BG02 (WHO) ;
Identifiers
	IUPAC name (8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione;
CAS Number	566-48-3 ;
PubChem CID	11273;
ChemSpider	10799 ;
UNII	PUB9T8T355;
KEGG	D07260 ;
ChEBI	CHEBI:75172 ;
ChEMBL	ChEMBL132530 ;
CompTox Dashboard (EPA)	DTXSID3034113 ;
ECHA InfoCard	100.153.838
Chemical and physical data
Formula	C19H26O3
Molar mass	302.408 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4C(/O)=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4;
	InChI InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1 ; Key:OSVMTWJCGUFAOD-KZQROQTASA-N ;
	(what is this?) (verify)

Formestane (trade name Lentaron), also known as 4-hydroxyandrost-4-ene-3,17-dione, is a type I, steroidal, selective aromatase inhibitor.^[1] It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.

Formestane is often used to suppress the production of estrogens from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a weak aromatase inhibitor.

References

^ Pérez Carrión R, Alberola Candel V, Calabresi F, et al. (1994). "Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer". Ann. Oncol. 5 Suppl 7: S19–24. PMID 7873457.

Template:Steroid hormone metabolism modulators

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

This article about a steroid is a stub. You can help Wikipedia by expanding it.

[pmid7873457-1] Pérez Carrión R, Alberola Candel V, Calabresi F, et al. (1994). "Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer". Ann. Oncol. 5 Suppl 7: S19–24. PMID 7873457.

[1]