3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||g·mol−1 163.220|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide. In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base. The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.
- C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 568–. ISBN 978-0-412-46630-4.
- Laboratory and Scientific Section (2006). Recommended methods of the identification and analysis of amphetamine, methamphetamine, and their ring-substituted analogues in seized materials (PDF). New York: United Nations Office on Drugs and Crime Vienna. ISBN 92-1-148208-9. Retrieved 14 October 2013.
- Kram, TC (July 1979). "Reidentification of a major impurity in illicit amphetamine". Journal of Forensic Sciences. 24 (3): 596–9. PMID 541629.
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