The park contains several distinct periods in human history. During the early historical period Fort George Island was known as Alicamani. It was the location of the village of Alicamani, a major village of the Timucua chiefdom known as the Saturiwa. Timucua influence is noted by the presence of middens, large mounds that are compiled of massive middens or shell mounds filled with discarded food byproducts. On Fort George Island, the shells were primarily oysters. The island was later home to the Spanish mission of San Juan del Puerto, the primary mission to the Saturiwa.
Activities include off-road bicycling, hiking, boating, canoeing, kayaking, and fishing. Amenities include a 4.4-mile (7.1 km)-long loop bicycle trail, boat ramp, a 3-mile (4.8 km) hiking/biking trail, and a beach. The park is open from 8:00 am until sundown year round.