FOSL1

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FOSL1
Identifiers
AliasesFOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDsMGI: 107179 HomoloGene: 3967 GeneCards: FOSL1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for FOSL1
Genomic location for FOSL1
Band11q13.1Start65,892,049 bp[1]
End65,900,573 bp[1]
RNA expression pattern
PBB GE FOSL1 213250 at fs.png

PBB GE FOSL1 204420 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300844
NM_001300855
NM_001300856
NM_001300857
NM_005438

NM_010235

RefSeq (protein)

NP_001287773
NP_001287784
NP_001287785
NP_001287786
NP_005429

NP_034365

Location (UCSC)Chr 11: 65.89 – 65.9 MbChr 19: 5.45 – 5.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[5][6]

Function[edit]

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[6]

Interactions[edit]

FOSL1 has been shown to interact with USF1 (human gene)[7] and C-jun.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175592 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024912 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490. 
  6. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  7. ^ a b Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.