Charles began his career in broadcasting in St. Louis, Missouri as an overnight reporter, news writer and assignment editor at KSDK-TV. A year later, he became a weekend sports anchor at WDTN in Dayton, Ohio. After three years in Dayton, Charles became the weekend sports anchor at WHDH-TV in Boston.
Additionally within the NBC family of networks, Charles was an anchor and reporter for NBC Sports, where he anchored the weekend Sportsdesk show and provided live reports and interviews for NBA on NBC. He also anchored sports at WNBC in New York City while working for NBC Sports.
Charles joined NFL Network at the start of the 2006 season and shared duties as host of NFL Total Access with Rich Eisen. From 2010 to 2013, Charles hosted NFL GameDay Final, joining Steve Mariucci, Deion Sanders and Michael Irvin to cap off all of Sunday’s action with the latest highlights, interviews and analysis from each game. During NFL Network’s Thursday Night Football schedule from 2010 to 2013, Charles, alongside analysts Kurt Warner, Sterling Sharpe, Jay Glazer, Brian Billick and Jim Mora, hosted Thursday Night Kickoff Presented by Sears from Los Angeles. He was also a studio host for NFL Network's coverage of the Arena Football League.
- "Fran Charles joins MLB Network's On-Air Talent Lineup". News. MLB.com. March 4, 2013.