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Franceschetto Cybo (baptized Francesco) (c. 1450 – 25 July 1519) was an Italian nobleman, the illegitimate son of Pope Innocent VIII (Giovanni Battista Cybo).
Despite his exceeding passion for card playing, he received from his father important positions in the Papal States: governor of Rome (1488), the fiefs of Cerveteri and Anguillara (1490) and the title of Count of the Lateran Palace. In 1490 he attempted to steal the Papal treasure.
Two years later, after Innocent VIII's death, he moved to Tuscany and Genoa, but could return to Rome thanks to the election of the more favourable Pope Julius II (1503). Julius gave him the title of Duke of Spoleto.