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Francis I or Francis the First may refer to:
- Francesco I Gonzaga (1366–1407)
- Francis I, Duke of Brittany (1414–1450, reigned 1442–1450)
- Francis I, Duke of Lorraine (1517–1545, reigned 1544–1545)
- Francis I of France (1494–1547, reigned 1515–1547)
- Francesco I de' Medici, Grand Duke of Tuscany (1541–1587, reigned 1574–1587)
- Francis I of Beauharnais, leading noble of the French House of Beauharnais (died 1587)
- Francesco I d'Este, Duke of Modena (1644–1658)
- Francis I, Holy Roman Emperor (1708–1765, reigned 1745–1765)
- Francis I (Erbach-Erbach) (1754–1823), Count of Erbach
- Francis I of the Two Sicilies (1777–1830, reigned 1825–1830)
- Francis II, Holy Roman Emperor, also known as Francis I, Emperor of Austria, (1768–1835, reigned 1804–1835)
- Francis V, Duke of Modena (1819–1875), known to Jacobites as Francis I of England, Scotland, France and Ireland.
- Franz I, Prince of Liechtenstein (1853–1938)
- Pope Francis (born 1936), Pope since 2013
- Francis the First, an opera composed by Edward Loder
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