He was born in Villa de Sinaloa, Mexico, the son of Juan José Sepúlveda (born 1720) and Ana María Josefa García (born 1720).
He married María Candelaria de Redondo in 1762.
Sepúlveda's eldest son, Juan José Sepúlveda (1764–1808), and his fifth son, Francisco Sepúlveda °(1775–1853), became progenitors of two distinguished branches of the family. Sepulveda Boulevard, the longest street in the City and County of Los Angeles, is named for the Sepúlveda family.
- Rudecinda Lo Buglio (1970) Sepulveda of Alta California: 1781-1822, Antepasados, vol. 1, no. 1, Los Californianos.
- Rudecinda Lo Buglio (1976) Sepulveda of Alta California: 1781-1822, Antepasados, vol. 1, no. 4, Los Californianos.
- Sepulveda's in California
- Pio Pico Genealogy Database
- Sepulveda Family
- Northrop, Marie E. (1986). Spanish-Mexican Families of Early California: 1769-1850, Volumes I, II & III. Southern California Genealogical Society, Burbank, California.
- Pitt, Leonard; Ramón A. Gutiérrez (1999). Decline of the Californios: A Social History of the Spanish-Speaking Californians, 1846-1890. University of California Press. ISBN 978-0-520-21958-8.