|Born||15 March 1614
Hanau, Holy Roman Empire
|Died||19 November 1672 (aged 58)
Leiden, Republic of the United Netherlands
|Doctoral advisor||Adolph Vorstius
|Other academic advisors||Otto Heurnius|
|Doctoral students||Burchard de Volder|
|Other notable students||Ehrenfried von Tschirnhaus|
Jan Baptist van Helmont
Franciscus Sylvius (15 March 1614 – 19 November 1672), born Franz de le Boë, was a Dutch physician and scientist (chemist, physiologist and anatomist) who was an early champion of Descartes', Van Helmont's and William Harvey's work and theories. He was one of the earliest defenders of the theory of circulation of the blood in the Netherlands, and commonly falsely cited as the inventor of gin.
Sylvius, a latinization of "de le Boë" translated as "of the woods", was born in Hanau, Germany to an affluent family originally from Cambrai, but worked and died in Netherlands. He studied medicine at the Protestant Academy of Sedan, and from 1632–1634 in Leiden under Adolph Vorstius and Otto Heurnius. In 1634 he held a disputation Positiones variae medicae under the presidency of Vorstius, in which he defended the proposition that there should be a pulmonary circulation. After that Sylvius made a study tour to Jena and Wittenberg, and on 16 March 1637 he defended a thesis entitled De animali motu ejusque laesionibus at the University of Basel under the presidency of Emmanuel Stupanus. After practicing medicine in his hometown Hanau he returned to Leiden in 1639 to lecture. In this period he became famous for his demonstrations on circulation. From 1641 on he had a lucrative medical practice in Amsterdam. While in Amsterdam he met Glauber, who introduced him to chemistry. In 1658 he was appointed the professor of medicine at the University of Leiden and was paid 1800 guilders which was twice the usual salary. He was the University's Vice-Chancellor in 1669-70.
In 1669 Sylvius founded the first academic chemical laboratory . For this reason, the building in which the Institute of Biology of Leiden University is housed has the name Sylvius Laboratory. His most famous students were Jan Swammerdam, Reinier de Graaf, Niels Stensen and Burchard de Volder.
He founded the Iatrochemical School of Medicine, according to which all life and disease processes are based on chemical actions. That school of thought attempted to understand medicine in terms of universal rules of physics and chemistry. Sylvius also introduced the concept of chemical affinity as a way to understand the way the human body uses salts and contributed greatly to the understanding of digestion and of bodily fluids. The most important work he published was Praxeos medicae idea nova (New Idea in Medical Practice, 1671). Specifically, he explained that digestion is a result of the chemical reactions of acids and bases coming from pancreatic, stomach, and saliva secretions.
He researched the structure of the brain and was credited as the discoverer of the cleft in the brain known as Sylvian fissure by Caspar Bartholin in his 1641 book Casp. Bartolini Institutiones Anatomicae In this book, it is noted that in the preface that “We can all measure the nobility of Sylvius’s brain and talent by the marvelous, new structure of the brain” And also, “In the new images of the brain, the engraver followed the design and scalpel of the most thorough Franciscus Sylvius, to whom we owe, in this part, everything that the brain has the most, or the most wonderful of”
However Caspar Bartholin died in 1629 and Franciscus Sylvius only started medicine in 1632 and it has been argued that the words in this word describing the Sylvian fissure are either by his son Thomas Bartholin or indeed Franciscus Sylvius. In 1663 in his Disputationem Medicarum, Franciscus Sylvius under his own name described the lateral fissure: "Particularly noticeable is the deep fissure or hiatus which begins at the roots of the eyes (oculorum radices) [...] it runs posteriorly above the temples as far as the roots of the brain stem (medulla radices). [...] It divides the cerebrum into an upper, larger part and a lower, smaller part".
- Franciscus Sylvius at the Mathematics Genealogy Project
- Digitaal Wetenschapshistorisch Centrum (DWC) - KNAW: "Franciscus dele Boë", PDF p
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- Lindemann, Mary (2010). Medicine and Society in Early Modern Europe. Cambridge University Press. p. 103. ISBN 978-0-521-73256-7.
- Collice, M; Collice, R; Riva, A (2008). "Who discovered the sylvian fissure?". Neurosurgery. 63 (4): 623–8. doi:10.1227/01.NEU.0000327693.86093.3F. PMID 18981875.
- Webmineral, retrieved 2011-10-05.
- Eric J. Sluijter, Marlies Enklaar, Paul Nieuwenhuizen (1988) Leidse fijnschilders: van Gerrit Dou tot Frans Mieris de Jonge, 1630-1760.