Frank Thomas may refer to:
- Frank Thomas (American football) (1898–1954), American football player and coach
- Frank Thomas (animator) (1912–2004), one of Walt Disney's team of animators known as the Nine Old Men
- Frank Thomas (bishop) (1930–1988), English prelate of the Roman Catholic Church.
- Frank Thomas (cricketer) (1877-1924), English cricketer
- Frank Thomas (designated hitter) (born 1968), Major League Baseball player in the American League from 1990 to 2008, Hall of Famer
- Frank Thomas (outfielder) (born 1929), Major League Baseball player in the National League from 1951 to 1966
- Frank Thomas (comics) (1914–1968), American cartoonist, creator of The Eye and Fantom of the Fair
- Frank Thomas (musician) (born 1943), American singer, songwriter and guitarist
- Frank Thomas (Australian footballer) (1905-2001), Australian rules footballer who played with Hawthorn and Sturt.
- Frank Thomas (French songwriter) (1936–2017), French songwriter
- Frank M. Thomas (1889–1989), American actor, father of Frankie Thomas
- Frankie Thomas (1921–2006), American actor and author
- Frankie Thomas (cyclist) (born 1907 – death date unattested), Australian cyclist
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