Frank Uhlmann

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Frank Uhlmann
Frank Uhlmann FRS.jpg
Frank Uhlmann in 2015, portrait via the Royal Society
Alma mater University of Tübingen (PhD)
Awards
Scientific career
Fields
Institutions
Thesis Reconstitution and characterisation of human replication factor C (1997)
Website crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann

Frank Uhlmann FRS[1] is a group leader at the Francis Crick Institute in London.[6][7][8][9][10][11][12]

Education[edit]

Uhlmann was educated at the University of Tübingen where he was awarded a PhD in 1997.[4][13] During his PhD, he worked with Jerard Hurwitz at the Memorial Sloan Kettering Cancer Center in New York City.[14][15][16]

Career[edit]

Following his PhD, Uhlmann moved to the Research Institute of Molecular Pathology in Vienna for postdoctoral research with Kim Nasmyth. In 2000, he established a laboratory at the Imperial Cancer Research Fund (now Cancer Research UK)[17] in London, which ultimately became part of the Francis Crick Institute.[16]

Awards and honours[edit]

Uhlmann was elected a Fellow of the Royal Society (FRS) in 2015. His certificate of election reads:

In 2006, Uhlmann was also elected a member of the European Molecular Biology Organization (EMBO)[2] and awarded the EMBO Gold Medal.[5][3]

References[edit]

  1. ^ a b c "Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute". London: The Royal Society. Archived from the original on 2015-05-02.
  2. ^ a b "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 2015-03-16.
  3. ^ a b Uhlmann, F. (2007). "What is your assay for sister-chromatid cohesion?". The EMBO Journal. 26 (22): 4609–4618. doi:10.1038/sj.emboj.7601898. PMC 2080813. PMID 17962808.
  4. ^ a b "Frank Uhlmann: Mechanism and control of chromosome segregation". The Crick Institute. Archived from the original on 2015-05-24.
  5. ^ a b "Frank Uhlmann of London Research Institute wins 'EMBO Gold'". EMBO. Archived from the original on 2015-04-14.
  6. ^ Frank Uhlmann's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ^ Uhlmann, F; Lottspeich, F; Nasmyth, K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature. 400 (6739): 37–42. doi:10.1038/21831. PMID 10403247.
  8. ^ Uhlmann, F; Wernic, D; Poupart, M. A.; Koonin, E. V.; Nasmyth, K (2000). "Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast". Cell. 103 (3): 375–86. doi:10.1016/s0092-8674(00)00130-6. PMID 11081625.
  9. ^ Tóth, A; Ciosk, R; Uhlmann, F; Galova, M; Schleiffer, A; Nasmyth, K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes & Development. 13 (3): 320–33. doi:10.1101/gad.13.3.320. PMC 316435. PMID 9990856.
  10. ^ Nasmyth, K; Peters, J. M.; Uhlmann, F (2000). "Splitting the chromosome: Cutting the ties that bind sister chromatids". Science. New York, N.Y. 288 (5470): 1379–85. doi:10.1126/science.288.5470.1379. PMID 10827941.
  11. ^ Godfrey, M; Kuilman, T; Uhlmann, F (2015). "Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast". PLOS Genetics. 11 (1): e1004907. doi:10.1371/journal.pgen.1004907. PMC 4287440. PMID 25569132. open access publication – free to read
  12. ^ Cheng, T. M.; Heeger, S; Chaleil, R. A.; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, P. A.; Uhlmann, F (2015). "A simple biophysical model emulates budding yeast chromosome condensation". eLife. 4. doi:10.7554/eLife.05565. PMC 4413874. PMID 25922992. open access publication – free to read
  13. ^ Uhlmann, Frank (1997). Reconstitution and characterization of human replication factor C (PhD thesis). University of Tübingen. OCLC 51443586.
  14. ^ Uhlmann, F; Gibbs, E; Cai, J; O'Donnell, M; Hurwitz, J (1997). "Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication". The Journal of Biological Chemistry. 272 (15): 10065–71. doi:10.1074/jbc.272.15.10065. PMID 9092550.
  15. ^ Uhlmann, F; Cai, J; Flores-Rozas, H; Dean, F. B.; Finkelstein, J; O'Donnell, M; Hurwitz, J (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6521–6. doi:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
  16. ^ a b "Frank Uhlmann biography". London: Francis Crick Institute. Archived from the original on 2015-05-25.
  17. ^ "Frank Uhlmann: Understanding how cells divide". Cancer Research UK. Archived from the original on 2015-05-27.