Frank Uhlmann

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Frank Uhlmann
Frank Uhlmann FRS.jpg
Frank Uhlmann in 2015, portrait via the Royal Society
Alma mater University of Tübingen (PhD)
Scientific career
Thesis Reconstitution and characterisation of human replication factor C (1997)

Frank Uhlmann FRS[1] is a group leader at the Francis Crick Institute in London.[6][7][8][9][10][11][12]


Uhlmann was educated at the University of Tübingen where he was awarded a PhD in 1997.[4][13] During his PhD, he worked with Jerard Hurwitz at the Memorial Sloan Kettering Cancer Center in New York City.[14][15][16]


Following his PhD, Uhlmann moved to the Research Institute of Molecular Pathology in Vienna for postdoctoral research with Kim Nasmyth. In 2000, he established a laboratory at the Imperial Cancer Research Fund (now Cancer Research UK)[17] in London, which ultimately became part of the Francis Crick Institute.[16]

Awards and honours[edit]

Uhlmann was elected a Fellow of the Royal Society (FRS) in 2015. His certificate of election reads:

In 2006, Uhlmann was also elected a member of the European Molecular Biology Organization (EMBO)[2] and awarded the EMBO Gold Medal.[5][3]


  1. ^ a b c "Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute". London: The Royal Society. Archived from the original on 2015-05-02.
  2. ^ a b "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 2015-03-16.
  3. ^ a b Uhlmann, F. (2007). "What is your assay for sister-chromatid cohesion?". The EMBO Journal. 26 (22): 4609–4618. doi:10.1038/sj.emboj.7601898. PMC 2080813. PMID 17962808.
  4. ^ a b "Frank Uhlmann: Mechanism and control of chromosome segregation". The Crick Institute. Archived from the original on 2015-05-24.
  5. ^ a b "Frank Uhlmann of London Research Institute wins 'EMBO Gold'". EMBO. Archived from the original on 2015-04-14.
  6. ^ Frank Uhlmann's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ^ Uhlmann, F; Lottspeich, F; Nasmyth, K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature. 400 (6739): 37–42. doi:10.1038/21831. PMID 10403247.
  8. ^ Uhlmann, F; Wernic, D; Poupart, M. A.; Koonin, E. V.; Nasmyth, K (2000). "Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast". Cell. 103 (3): 375–86. doi:10.1016/s0092-8674(00)00130-6. PMID 11081625.
  9. ^ Tóth, A; Ciosk, R; Uhlmann, F; Galova, M; Schleiffer, A; Nasmyth, K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes & Development. 13 (3): 320–33. doi:10.1101/gad.13.3.320. PMC 316435. PMID 9990856.
  10. ^ Nasmyth, K; Peters, J. M.; Uhlmann, F (2000). "Splitting the chromosome: Cutting the ties that bind sister chromatids". Science. New York, N.Y. 288 (5470): 1379–85. doi:10.1126/science.288.5470.1379. PMID 10827941.
  11. ^ Godfrey, M; Kuilman, T; Uhlmann, F (2015). "Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast". PLOS Genetics. 11 (1): e1004907. doi:10.1371/journal.pgen.1004907. PMC 4287440. PMID 25569132. open access publication – free to read
  12. ^ Cheng, T. M.; Heeger, S; Chaleil, R. A.; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, P. A.; Uhlmann, F (2015). "A simple biophysical model emulates budding yeast chromosome condensation". eLife. 4. doi:10.7554/eLife.05565. PMC 4413874. PMID 25922992. open access publication – free to read
  13. ^ Uhlmann, Frank (1997). Reconstitution and characterization of human replication factor C (PhD thesis). University of Tübingen. OCLC 51443586.
  14. ^ Uhlmann, F; Gibbs, E; Cai, J; O'Donnell, M; Hurwitz, J (1997). "Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication". The Journal of Biological Chemistry. 272 (15): 10065–71. doi:10.1074/jbc.272.15.10065. PMID 9092550.
  15. ^ Uhlmann, F; Cai, J; Flores-Rozas, H; Dean, F. B.; Finkelstein, J; O'Donnell, M; Hurwitz, J (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6521–6. doi:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
  16. ^ a b "Frank Uhlmann biography". London: Francis Crick Institute. Archived from the original on 2015-05-25.
  17. ^ "Frank Uhlmann: Understanding how cells divide". Cancer Research UK. Archived from the original on 2015-05-27.