Her work as an activist began at the age of 80 when her eldest grandchild was diagnosed with AIDS and continued for 18 years until her death in 2001. She helped establish The AIDS Project, which became Maine's largest AIDS service organization, and co-founded the Peabody House assisted living facility. In 2002, after her death, the two organizations merged, becoming the Frannie Peabody Center.
- "Frances W. "Frannie" Peabody" (PDF). State of Maine - Department of Health and Human Services. Retrieved 27 February 2016.
- "About Frannie Peabody Center". Maine Harm Reduction Alliance. Retrieved 27 February 2016.
- Frannie Peabody Center - official website