|Date of birth||September 10, 1897|
|Place of birth||Columbus, Ohio, United States|
|Date of death||July 2, 1967(aged 69)|
|Place of death||Columbus, Ohio, United States|
|Position(s)||End, Fullback, Tackle|
|Height||6 ft 5 in (196 cm)|
|Weight||250 lb (110 kg)|
Frederick W. Nesser (September 10, 1897 - July 2, 1967) was a professional American football player in the "Ohio League" and the early National Football League for the Columbus Panhandles. He was also a member of the Nesser Brothers, a group consisting of seven brothers who made-up the most famous football family in the United States from 1907 until the mid-1920s. He was the tallest and biggest of the football-playing brothers at six feet five inches and 250 pounds. He played mostly tackle or end, but sometimes he lined up in the backfield, to provide blocking.
Around 1987 Fred's daughter, Vera, tried to get the city of Columbus to name a street for the Nesser Brothers. Her request was turned down.
- Peterson, Robert W. (1997-01-01). Pigskin: The Early Years of Pro Football. Oxford University Press. p. 262. ISBN 0-19-511913-4.
- PFRA Research. "Thorpe Arrives:1915" (PDF). Coffin Corner. Professional Football Researchers Association: 1–5. Archived from the original (PDF) on 2012-03-11.
- Forgotten NFL Family: the Nesser Brothers of Columbus, Ohio