He is the son of Joseph S. Iseman, a noted New York City attorney and partner at Paul, Weiss, Rifkind, Wharton & Garrison LLP. He graduated from Yale College, with a B.A. in English literature, and is a member of its Elizabethan Club.
He founded Caxton-Iseman Capital LLC in 1993 in partnership with Caxton Associates. Caxton-Iseman Capital LLC announced on December 21, 2007, that it had completed its spin-off from Caxton Associates to form an independent private equity fund to be named CI Capital Partners LLC. Frederick Iseman currently serves as the chairman and chief executive officer of CI Capital Partners LLC.
He is chairman of CI Capital Partners' portfolio companies, including Ply Gem Industries, American Residential Services, Conney Safety Products, KIK Custom Products, and CoVant. He is also a director of CI Capital Partners' portfolio companies including Transplace, Tech Air, Interactive Health Solutions, Galls, IntraPac, A-T Solutions, Foundation Building Materials, and Total Fleet Solutions. Iseman is also a member of the advisory board of investment firm STAR Capital in London. Iseman was the chairman of Anteon International Corp. until Anteon's sale to General Dynamics Corp. in June 2006. Anteon closed its initial public offering in 2002.
He sits on the boards of directors of the International Rescue Committee a large foreign aid NGO. He also serves on the international council of the Belfer Center for Science and International Affairs at the John F. Kennedy School of Government, Harvard University and is a member of the advisory board of the Nuclear Threat Initiative, whose chairman is former senator Sam Nunn.
His philanthropic interests include medical research at Columbia-Presbyterian Medical Center, the Frederick Iseman Theater at Yale University, the Wharton Institute, the Taub Institute for Brain Research, oncology, immunology, and other disciplines. As a member of the board of directors of The Metropolitan Opera, Iseman underwrote the production of Dimitri Shostakovich's The Nose for the 2009–2010 season. He is also on the board of trustees of Carnegie Hall and is chairman of the Mariinsky Foundation of America. Iseman is also a Harold Pratt Fellow of the Council on Foreign Relations and served on that Council's Independent Task Force on U.S. Nuclear Weapons Policy. He was the lead sponsor of the Yale Center for the Study of Globalization's 2008 conference on nuclear weapons. Iseman is a major supporter of Stanford University's Preventive Defense Project, a part of the Center for International Security and Cooperation at the Freeman Spogli Institute and the Yale Center for Genocide Studies. His support of the latter allowed Adam Jones to complete his book, Genocide: A Comprehensive Introduction.
He resides in New York City with his two children, a daughter and son. He purchased an apartment in 907 Fifth Avenue on the Upper East Side, formerly owned by the heiress Huguette M. Clark (1906–2011).
- Joseph S. Iseman, 89, Lawyer and Educator, Dies, The New York Times, 1 May 2006
- Caxton-Iseman Capital Announces Spin-Off From Caxton Associates (Press Release)
- Lou Whiteman, "Smart Fishing,"The Deal, July 6, 2006
- David Carey, "A Consummate Partner," The Deal, October 8, 2004
- "Let Corporate Takeovers Keep Rolling", The New York Times, December 1, 1986.
- Iseman, Frederick - Articles (Harper's Magazine)
- The Talk of the Town: The Ride: The New Yorker
- IMDb - Someone to Love
- COLUMBIA UNIVERSITY P&S Annual Report
- Yale Dedicates the Frederick Iseman Theater
- The Metropolitan Opera Board of Directors
- The Met Expands its Repertory (Press Release)
- Carnegie Hall Board of Trustees
- White Nights Foundation of America Board of Directors
- Council on Foreign Relations - U.S. Nuclear Weapons Policy
- Genocide Studies Program at Yale University
- Genocide Studies Program Annual Report 2007
- Bill Dedman and Paul Clark Newell, Jr., Empty Mansions: The Mysterious Life of Huguette Clark and the Loss of one of the World's Greatest Fortunes, London: Atlantic Books, 2013, p. 349