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Friedrich Gustav Jakob Henle

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Friedrich Gustav Jakob Henle
Born(1809-07-09)9 July 1809
Died13 May 1885(1885-05-13) (aged 75)
Alma materUniversity of Heidelberg
University of Bonn
Known forLoop of Henle, Handbook of Systematic Human Anatomy
Scientific career
FieldsPathology, anatomy
Doctoral advisorJohannes Peter Müller[1]

Friedrich Gustav Jakob Henle (German: [ˈhɛnlə]; 9 July 1809 – 13 May 1885) was a German physician, pathologist, and anatomist. He is credited with the discovery of the loop of Henle in the kidney. His essay, "On Miasma and Contagia," was an early argument for the germ theory of disease.[2] He was an important figure in the development of modern medicine.[3]


Jakob Henle

Henle was born in Fürth, Bavaria, to Simon and Rachel Diesbach Henle (Hähnlein). He was Jewish.[4] After studying medicine at Heidelberg and at Bonn, where he took his doctor's degree in 1832, he became prosector in anatomy to Johannes Müller at Berlin. During the six years he spent in that position he published a large amount of work, including three anatomical monographs on new species of animals and papers on the structure of the lymphatic system, the distribution of epithelium in the human body, the structure and development of the hair, and the formation of mucus and pus.[5] He also developed a friendship with another assistant of Müller, Theodor Schwann, which later became famous for his cell theory.[6]

In 1840, he accepted the chair of anatomy at Zürich and in 1844 he was called to Heidelberg, where he taught anatomy, physiology, and pathology. About this period he was engaged on delineating his complete system of general anatomy, which formed the sixth volume of the new edition of Samuel Thomas von Sömmering's treatise, published at Leipzig between 1841 and 1844. While at Heidelberg he published a zoological monograph on the sharks and rays, in conjunction with his master Müller, and in 1846 his famous Manual of Rational Pathology began to appear; this marked the beginning of a new era in pathological study, since in it physiology and pathology were treated, in Henle's own words, as branches of one science, and the facts of disease were systematically considered with reference to their physiological relations.[5]

In 1852, he moved to Göttingen, whence he issued three years later the first instalment of his great Handbook of Systematic Human Anatomy, the last volume of which was not published until 1873. This work was perhaps the most complete and comprehensive of its kind at that time, and it was remarkable not only for the fullness and minuteness of its anatomical descriptions but also for the number and excellence of the illustrations with which they elucidated minute anatomy of the blood vessels, serous membranes, kidney, eye, nails, central nervous system, etc. He discovered the loop of Henle and Henle's tubules, two anatomical structures in the kidney.[5]

Other anatomical and pathological findings associated with his name are:[5]

Henle developed the concepts of contagium vivum and contagium animatum, respectively (Von den Miasmen und Kontagien, 1840) – thereby following ideas of Girolamo Fracastoro and the work of Agostino Bassi; thus co-founding the theory of microorganisms as the cause of infective diseases. He did not find a special species of bacteria himself – this was achieved by his student Robert Koch. Those two put up the fundamental rules of cleanly defining disease-causing microbes: the Henle Koch postulates.[5]

In 1870, he was elected a foreign member of the Royal Swedish Academy of Sciences. He died in Göttingen, 13 May 1885.[5]


  • Ueber die Ausbreitung des Epithelium im menschlichen Körper (1838)
  • Allgemeine Anatomie: Lehre von den Mischungs- und Formbestandtheilen des menschlichen Körpers (1841)
  • Handbuch der rationellen Pathologie (1846–1853)
  • Handbuch der systematischen Anatomie des Menschen (1855–1871)
  • Vergleichend-anatomische Beschreibung des Kehlkopfes mit besonderer Berücksichtigung des Kehlkopfes der Reptilien (1839)
  • Pathologische Untersuchungen (1840)
  • Zur Anatomie der Niere (1863)

See also[edit]


  1. ^ "Neurotree - Friedrich Gustav Jakob Henle". Neurotree.org. Retrieved 30 March 2019.
  2. ^ See:
    • Henle, Jacob (1840). "Von den Miasmen und Contagien und von den miasmatisch-contagiösen Krankheiten [Of miasmas and contagions and of miasmic-contagious diseases]". Pathologische Untersuchungen [Pathology Investigations] (in German). Berlin, (Germany): August Hirschwald. pp. 1–82.
    • English translation: Rosen, George (1938). "On miasmata and contagia". Bulletin of the Institute of the History of Medicine. 4: 907–983.
  3. ^ Robinson, Victor, M.D. (1921). The Life of Jacob Henle. New York: Medical Life Co.{{cite book}}: CS1 maint: multiple names: authors list (link)
  4. ^ "HENLE, FRIEDRICH GUSTAV JACOB". Jewishencyclopedia.com. Retrieved 30 March 2019.
  5. ^ a b c d e f Chisholm 1911, p. 269
  6. ^ Otis, Laura (2007). Müller's lab. Oxford: Oxford university press. ISBN 978-0-19-530697-2.

 This article incorporates text from a publication now in the public domainChisholm, Hugh, ed. (1911). "Henle, Friedrich Gustav Jakob". Encyclopædia Britannica. Vol. 13 (11th ed.). Cambridge University Press. p. 269.

External links[edit]