Varenholt had studied Chemistry in Münster and started his professional career at the federal Umweltbundesamt (environmental protection agency) in Berlin and the Ministry for Environment of Hesse. From 1984 till 1990 he was in a leading role in Hamburg, first as Staatsrat for environment, 1990 to 1991 for the administral Senatskanzlei, and the Umweltsenator (senator for the environment) in Hamburg from 1991 to 1997.
In 1998 he entered the energy industry and until 2001 was on the Board of Deutsche Shell AG, a Shell subsidiary. In 2001 he moved to post of CEO of the wind turbine company REpower Systems AG and remained there until 2007. From February 2008 to June 2012 he was CEO of electric power company RWE subsidiary RWE Innogy and remains on the supervisory board. Varenholt has a doctorate in Chemistry. In 1999 he was made an Honorary Professor of chemistry at the University of Hamburg.
Vahrenholt is skeptical of human-induced global warming. In 2012 Vahrenholt together with geologist Sebastian Lüning published Die kalte Sonne: warum die Klimakatastrophe nicht stattfindet (The Cold Sun: Why the Climate Crisis Isn't Happening), a book asserting that climate change is driven by variations in solar activity. They predict the Earth is entering a cooling phase due to periodic solar cycles, and will cool by 0.2 to 0.3 degrees C by 2035. Other contributors are Nir Shaviv, Werner Weber, Henrik Svensmark and Nicola Scafetta.