Fucosyltransferase 3

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Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Identifiers
Symbols FUT3 ; CD174; FT3B; FucT-III; LE; Les
External IDs OMIM111100 HomoloGene55438 ChEMBL: 3269 GeneCards: FUT3 Gene
EC number 2.4.1.65
RNA expression pattern
PBB GE FUT3 214088 s at tn.png
PBB GE FUT3 210398 x at tn.png
PBB GE FUT3 211882 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2525 n/a
Ensembl ENSG00000171124 n/a
UniProt P21217 n/a
RefSeq (mRNA) NM_000149.3 n/a
RefSeq (protein) NP_000140.1 n/a
Location (UCSC) Chr 19:
5.84 – 5.85 Mb
n/a
PubMed search [1] n/a

Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene.[1][2][3]

Function[edit]

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[3]

See also[edit]

References[edit]

  1. ^ Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (Aug 1990). "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase". Genes & Development 4 (8): 1288–303. doi:10.1101/gad.4.8.1288. PMID 1977660. 
  2. ^ Weston BW, Nair RP, Larsen RD, Lowe JB (Feb 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry 267 (6): 4152–60. PMID 1740457. 
  3. ^ a b "Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)". 

Further reading[edit]

  • Cameron HS, Szczepaniak D, Weston BW (Aug 1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". The Journal of Biological Chemistry 270 (34): 20112–22. doi:10.1074/jbc.270.34.20112. PMID 7650030. 
  • Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenetics and Cell Genetics 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588. 
  • Nishihara S, Nakazato M, Kudo T, Kimura H, Ando T, Narimatsu H (Jan 1993). "Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19". Biochemical and Biophysical Research Communications 190 (1): 42–6. doi:10.1006/bbrc.1993.1008. PMID 7916594. 
  • Nishihara S, Narimatsu H, Iwasaki H, Yazawa S, Akamatsu S, Ando T, Seno T, Narimatsu I (Nov 1994). "Molecular genetic analysis of the human Lewis histo-blood group system". The Journal of Biological Chemistry 269 (46): 29271–8. PMID 7961897. 
  • Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB (Aug 1994). "Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees". The Journal of Biological Chemistry 269 (33): 20987–94. PMID 8063716. 
  • Koda Y, Kimura H, Mekada E (Nov 1993). "Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals". Blood 82 (9): 2915–9. PMID 8219240. 
  • Elmgren A, Rydberg L, Larson G (Oct 1993). "Genotypic heterogeneity among Lewis negative individuals". Biochemical and Biophysical Research Communications 196 (2): 515–20. doi:10.1006/bbrc.1993.2280. PMID 8240322. 
  • Nishihara S, Yazawa S, Iwasaki H, Nakazato M, Kudo T, Ando T, Narimatsu H (Oct 1993). "Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals". Biochemical and Biophysical Research Communications 196 (2): 624–31. doi:10.1006/bbrc.1993.2295. PMID 8240337. 
  • Elmgren A, Börjeson C, Svensson L, Rydberg L, Larson G (1996). "DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system". Vox Sanguinis 70 (2): 97–103. doi:10.1111/j.1423-0410.1996.tb01300.x. PMID 8801770. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Orntoft TF, Vestergaard EM, Holmes E, Jakobsen JS, Grunnet N, Mortensen M, Johnson P, Bross P, Gregersen N, Skorstengaard K, Jensen UB, Bolund L, Wolf H (Dec 1996). "Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels". The Journal of Biological Chemistry 271 (50): 32260–8. doi:10.1074/jbc.271.50.32260. PMID 8943285. 
  • Elmgren A, Mollicone R, Costache M, Börjeson C, Oriol R, Harrington J, Larson G (Aug 1997). "Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII". The Journal of Biological Chemistry 272 (35): 21994–8. doi:10.1074/jbc.272.35.21994. PMID 9268337. 
  • Pang H, Liu Y, Koda Y, Soejima M, Jia J, Schlaphoff T, Du Toit ED, Kimura H (Jun 1998). "Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa". Human Genetics 102 (6): 675–80. doi:10.1007/s004390050760. PMID 9703429. 
  • Nishihara S, Hiraga T, Ikehara Y, Iwasaki H, Kudo T, Yazawa S, Morozumi K, Suda Y, Narimatsu H (Apr 1999). "Molecular behavior of mutant Lewis enzymes in vivo". Glycobiology 9 (4): 373–82. doi:10.1093/glycob/9.4.373. PMID 10089211. 
  • Yazawa S, Tanaka S, Nishimura T, Miyanaga K, Kochibe N (1999). "Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia". Experimental and Clinical Immunogenetics 16 (3): 125–30. doi:10.1159/000019104. PMID 10394050. 
  • Holmes EH, Yen TY, Thomas S, Joshi R, Nguyen A, Long T, Gallet F, Maftah A, Julien R, Macher BA (Aug 2000). "Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites". The Journal of Biological Chemistry 275 (32): 24237–45. doi:10.1074/jbc.M000888200. PMID 10816554. 
  • Grahn A, Elmgren A, Aberg L, Svensson L, Jansson PA, Lönnroth P, Larson G (Oct 2001). "Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples". Human Mutation 18 (4): 358–9. doi:10.1002/humu.1204. PMID 11668626. 
  • Roos C, Kolmer M, Mattila P, Renkonen R (Feb 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403. 

External links[edit]