Functional neurological symptom disorder

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A functional neurological disorder (FND) is a condition in which patients experience neurological symptoms such as weakness, movement disorders, sensory symptoms and blackouts.[1] The brain of a patient with functional neurological symptom disorder is structurally normal, but functions incorrectly.[2] According to consensus from the literature and from physicians and psychologists practicing in the field, functional symptoms are also called 'medically unexplained'. Historically, other terms have been used to describe these symptoms. Symptoms of functional neurological disorders are clinically recognisable, but are not categorically associated with a definable organic disease.[3] The intended contrast is with an organic brain syndrome, although the terms imply a level of certainty about causation that is often clinically unconfirmed. Subsets of functional neurological disorders include functional neurological symptom disorder (FNsD), conversion disorder, and psychogenic movement disorder/non-epileptic seizures. Functional neurological disorders are common in neurological services, accounting for up to one third of outpatient neurology clinic attendances, and associated with as much physical disability and distress as other neurological disorders.[1][4] The diagnosis is made based on positive signs and symptoms in the history and examination during consultation of a neurologist (see below). Physiotherapy is particularly helpful for patients with motor symptoms (weakness, gait disorders, movement disorders) and tailored cognitive behavioural therapy has the best evidence in patients with dissociative (non-epileptic) attacks.[5]

Signs and symptoms[edit]

There are a great number of symptoms experienced by those with a functional neurological disorder. It is important to note that the symptoms experienced by those with an FND are very real. At the same time, the origin of symptoms is complex since it can be associated with physical injury, severe psychological trauma (conversion disorder), and idiopathic neurological dysfunction. The core symptoms are those of motor or sensory function or episodes of altered awareness:

  • Limb weakness or paralysis
  • Blackouts (also called dissociative or non-epileptic seizures/attacks) – these may look like epileptic seizures or faints
  • Movement disorders including tremors, dystonia (spasms), myoclonus (jerky movements)
  • Visual symptoms including loss of vision or double vision
  • Speech symptoms including dysphonia (whispering speech), slurred or stuttering speech
  • Sensory disturbance including hemisensory syndrome (altered sensation down one side of the body)

Epidemiology and aetiology[edit]


Functional neurological disorders are a common problem, and are the second most common reason for a neurological outpatient visit after headache/migraine. Dissociative (non-epileptic) seizures account for about 1 in 7 referrals to neurologists after an initial seizure, and functional weakness has a similar prevalence to multiple sclerosis.[6]

Aetiology and mechanism[edit]

Epidemiological studies and meta-analysis have shown higher rates of depression and anxiety in patients with FND compared to the general population, but rates are similar to patients with other neurological disorders such as epilepsy or Parkinson's disease. This is often the case because of years of misdiagnosis and accusations of malingering.[7][8][9][10]

Diagnostic criteria[edit]

A diagnosis of a functional neurological disorder is dependent on positive features from the history and examination.

Positive features of functional weakness on examination include Hoover’s sign, when there is weakness of hip extension which normalises with contralateral hip flexion, and thigh abductor sign, weakness of thigh abduction which normalises with contralateral thigh abduction. Signs of functional tremor include entrainment and distractibility. The patient with tremor should be asked to copy rhythmical movements with one hand or foot. If the tremor of the other hand entrains to the same rhythm, stops, or if the patient has trouble copying a simple movement this may indicate a functional tremor. Functional dystonia usually presents with an inverted ankle posture or clenched fist. Positive features of dissociative or non-epileptic attacks include prolonged motionless unresponsiveness, long duration episodes (>2minutes) and symptoms of dissociation prior to the attack. These signs can be usefully discussed with patients when the diagnosis is being made.

Patients with functional movement disorders and limb weakness may experience symptom onset triggered by an episode of acute pain, a physical injury or physical trauma. They may also experience symptoms when faced with a psychological stressor, but this isn't the case for most patients. Patients with functional neurological disorders are more likely to have a history of another illness such as irritable bowel syndrome, chronic pelvic pain or fibromyalgia but this cannot be used to make a diagnosis. FND does not show up on blood tests or structural brain imaging such as MRI or CT scanning. However, this is also the case for many other neurological conditions so negative investigations should not be used alone to make the diagnosis. FND can, however, occur alongside other neurological diseases and tests may show non-specific abnormalities which cause confusion for doctors and patients.[11]

ICD-11 diagnostic criteria[edit]

The International Classification of Disease (ICD-11) which is due to be finalised in 2017 will have functional disorders within the neurology section for the first time.[12]


Functional neurological disorder is a common problem, with estimates suggesting that up to a third of neurology outpatients having functional symptoms.[13] In Scotland, around 5000 new cases of FND are diagnosed annually.[13] Furthermore, non-epileptic seizures account for 1 in 7 referrals to neurologists after an initial seizure, and functional weakness has a similar prevalence to multiple sclerosis.[13]


Historically, misdiagnosis rates have been low.[3][14]


Treatment requires a firm and transparent diagnosis based on positive features which both health professionals and patients can feel confident about. It is essential that the health professional confirms that this is a common problem which is genuine, not imagined and not a diagnosis of exclusion.

Confidence in the diagnosis does not improve symptoms, but appears to improve the efficacy of treatments such as physiotherapy which require altering established abnormal patterns of movement.

A multi-disciplinary approach to treating functional neurological disorder is recommended. Treatment options can include:

  • Physiotherapy and occupational therapy
  • Medication such as sleeping tablets, painkillers, anti-epileptic medications and anti-depressants (for patients suffering with depression co-morbid or for pain relief)

Physiotherapy with someone who understands functional disorders may be the initial treatment of choice for patients with motor symptoms such as weakness, gait (walking) disorder and movement disorders. Nielsen et al. have reviewed the medical literature on physiotherapy for functional motor disorders up to 2012 and concluded that the available studies, although limited, mainly report positive results.[15] Since then several studies have shown positive outcomes. In one study, up to 65% of patients were very much or much improved after five days of intensive physiotherapy even though 55% of patients were thought to have poor prognosis.[15] In a randomised controlled trial of physiotherapy there was significant improvement in mobility which was sustained on one year follow up.[16] In multidisciplinary settings 69% of patients markedly improved even with short rehabilitation programmes. Benefit from treatment continued even when patients were contacted up 25 months after treatment.[17]

For patients with severe and chronic FND a combination of physiotherapy, occupational therapy and cognitive behavioural therapy may be the best combination with positive studies being published in patients who have had symptoms for up to three years before treatment.

Cognitive behavioural therapy (CBT) alone may be beneficial in treating patients with dissociative (non-epileptic) seizures. A randomised controlled trial of patients who undertook 12 sessions of CBT which taught patients how to interrupt warning signs before seizure onset, challenged unhelpful thoughts and helped patients start activities they had been avoiding found a reduction in the seizure frequency with positive outcomes sustained at six month follow up. A large multicentre trial of CBT for dissociative (non-epileptic) seizures started in 2015 in the UK.[18]

For many patients with FND, accessing treatment can be difficult. Availability of expertise is limited and they may feel that they are being dismissed or told 'it's all in your head' especially if psychological input is part of the treatment plan. Some medical professionals are uncomfortable explaining and treating patients with functional symptoms. Changes in the diagnostic criteria, increasing evidence, literature about how to make the diagnosis and how to explain it and changes in medical training is slowly changing this.[19]

After a diagnosis of functional neurological disorder has been made, it is important that the neurologist explains the illness fully to the patient to ensure the patient understands the diagnosis.

Some, but not all patients with FND may experience low moods or anxiety due to their condition. However, they will often not seek treatment due being worried that a doctor will blame their symptoms on their anxiety or depression.[20]

It is recommended that the treatment of functional neurological disorder should be balanced and involve a whole-person approach. This means that it should include professionals from multiple departments, including neurologists, general practitioners (or primary health care providers), physiotherapists, occupational therapists. At the same time, ruling out secondary gain, malingering, conversion disorder and other factors, including the time and financial resources involved in assessing and treating patients who demand hospital resources but would be better served in psychological settings, must all be balanced.

Alternative diagnoses[edit]

Functional neurological symptom disorder can very rarely mimic many other conditions.[3] Some alternative diagnoses for FND that are often considered include:

The main caveat however is that these conditions can co-exist and can be the trigger for functional neurological disorder.


From the 18th century, there is a move from the idea of FND being caused being caused by the nervous system. This led to an understanding that it could affect both sexes. Jean Martin Charcot argued that, what would be later called FND, was caused by "a hereditary degeneration of the nervous system, namely a neurological disorder".[21]

In the 18th century, the illness was confirmed as being a neurological disorder but a small number of doctors still believed in the previous definition.[21] However, as early as 1874, doctors including W. B. Carpenter and J. A. Omerod began to speak out against this other term due to there being no evidence of its existence.[22]

Although the term "conversion disorder" has been in existence for many years, another term was still being used in the 20th century. However, by this point, it bore little resemblance to the original meaning, instead referring to symptoms which could not be explained by a recognised organic pathology, and was therefore believed to be the result of stress, anxiety, trauma or depression. The term fell out of favour of doctors over time due to the negative connotations this term held. Furthermore, critics pointed out that it can be challenging to find organic pathologies for all symptoms, and so the practice of diagnosing patients who suffered with such symptoms as imagining them led to the disorder being meaningless, vague and a sham-diagnosis, as it does not refer to any definable disease.[22]

Throughout its history, many patients have been misdiagnosed with conversion disorder when they had organic disorders such as tumours or epilepsy or vascular diseases. This has led to patient deaths, a lack of appropriate care and suffering for the patients. Eliot Slater, after studying the condition in the 1950s, was outspoken against the condition, as there has never been any evidence to prove that it exists. He stated that "The diagnosis of 'hysteria' is a disguise for ignorance and a fertile source of clinical error. It is, in fact, not only a delusion but also a snare".[22]

In 1980, the DSM III added 'conversion disorder' to its list of conditions. The diagnostic criteria for this condition are nearly identical to those used for hysteria. The diagnostic criteria were:

A. The predominant disturbance is a loss of or alteration in physical functioning suggesting a physical disorder. It is involuntary and medically unexplainable

B. One of the following must also be present:

  1. A temporal relationship between symptom onset and some external event of psychological conflict.
  2. The symptom allows the individual to avoid unpleasant activity.
  3. The symptom provides opportunity for support which may not have been otherwise available.

Many illnesses and injuries can cause an individual to avoid unpleasant activities, and can provide the opportunity for support, particularly from a doctor. This makes Criteria B meaningless for the most part, and therefore any patient whose symptoms satisfy Criteria A by being medically unexplained, could be diagnosed with Conversion Disorder.

Today, there is growing evidence that psychological stress does not cause FND. A recent study by the charity FNDHope found that psychological triggers affected only 30% of patients. Doctors are moving on to look at the role of the central nervous system in FND symptoms.


There was historically much controversy surrounding the FND diagnosis. Many doctors continue to believe that all FND patients have unresolved traumatic events (often of a sexual nature) which are being expressed in a physical way. However, some doctors do not believe this to be the case. Wessely and White have argued that FND may merely be an unexplained somatic illness (like fibromyalgia, irritable bowel syndrome, or chronic fatigue syndrome) rather than a psychiatric condition.[23]


  1. ^ a b Carson, A. et al. Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by disease'. J.Neurol.Neurosurg.Psychiatry 2011 Jul;82(7):810-3
  2. ^ Stone, J. et al. Who is referred to neurology clinics? - The diagnoses made in 3781 new patients. Clin. Neurol. Neurosurg. 112, 747–751 (2010).
  3. ^ a b c Stone, J.; Sharpe, M.; Rothwell, P. M.; Warlow, C. P. (2003-05-01). "The 12 year prognosis of unilateral functional weakness and sensory disturbance". Journal of Neurology, Neurosurgery & Psychiatry. 74 (5): 591–596. doi:10.1136/jnnp.74.5.591. ISSN 1468-330X. PMC 1738446. PMID 12700300.
  4. ^ Stone, J. et al. Who is referred to neurology clinics? - The diagnoses made in 3781 new patients. Clin. Neurol. Neurosurg. 112, 747–751 (2010)
  5. ^ Lehn, A. et al. Functional neurological disorders: mechanisms and treatment. J. Neurol. PMID 2641, (2015).
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  7. ^ Fiszman, A. & Kanner, A. M. in Gates and Rowan's Nonepileptic Seizures (eds. Schacter, S. & LaFrance Jr, W. C.) 3rd editio, 225–234 (Cambridge University Press, 2010).
  8. ^ Henningsen, P. Medically Unexplained Physical Symptoms, Anxiety, and Depression: A Meta-Analytic Review. Psychosom. Med. 65, 528–533 (2003).
  9. ^ Edwards, M. J., Stone, J. & Lang, A. E. From psychogenic movement disorder to functional movement disorder: It's time to change the name. Mov. Disord. 29, 849–852 (2014)
  10. ^ Kranick, S. et al. Psychopathology and psychogenic movement disorders. Mov. Disord. 26, 1844–1850 (2011)
  11. ^ Stone, J. et al. Systematic review of misdiagnosis of conversion symptoms and 'hysteria'. BMJ 331, 989 (2005).
  12. ^ Stone, J., Hallett, M., Carson, A., Bergen, D. & Shakir, R. Functional disorders in the Neurology section of ICD-11: A landmark opportunity. Neurology 83, 2299–301 (2014).
  13. ^ a b c "Neurological functional symptoms stepped care report". Retrieved 2015-11-25.
  14. ^ Stone, J. et al. Systematic review of misdiagnosis of conversion symptoms and ‘hysteria’. BMJ 331, 989 (2005).
  15. ^ a b Nielsen, G., Stone, J. & Edwards, M. J. Physiotherapy for functional (psychogenic) motor symptoms: a systematic review. J. Psychosom. Res. 75, 93–102 (2013)
  16. ^ Jordbru, A. A., Smedstad, L. M., Klungsoyr, O. & Martinsen, E. W. Psychogenic gait: a randomized controlled trial on effect on rehabilitation. Clin. Rehabil.
  17. ^ McCormack, R. et al. Specialist inpatient treatment for severe motor conversion disorder: a retrospective comparative study. J. Neurol. Neurosurg. Psychiatry 85, 895–900 (2014)
  18. ^ [([1])]
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  20. ^ "". Retrieved 2016-02-07.
  21. ^ a b Tasca, Cecilia; Rapetti, Mariangela; Carta, Mauro Giovanni; Fadda, Bianca (2012-10-19). "Women And Hysteria In The History Of Mental Health". Clinical Practice and Epidemiology in Mental Health : CP & EMH. 8: 110–119. doi:10.2174/1745017901208010110. ISSN 1745-0179. PMC 3480686. PMID 23115576.
  22. ^ a b c Webster, Richard. "Sigmund Freud: somatization, medicine and misdiagnosis". Retrieved 2016-02-21.
  23. ^ Wessely, Simon; White, Peter D. (2004-08-01). "There is only one functional somatic syndrome". The British Journal of Psychiatry. 185 (2): 95–96. doi:10.1192/bjp.185.2.95. ISSN 0007-1250. PMID 15286058.

External links[edit]

Online resources include:

  • Neurosymptoms is written by Dr Jon Stone a Scottish neurologist.
  • FND Hope is registered charity in the United States and non-profit organization in the United Kingdom. They collaborate with Dr. Jon Stone and Dr. Mark Edwards.
  • FND Dimensions is a registered charity in England and Wales who aim "to develop a network of 'peer support groups' across the UK either in face to face meetings or online via methods such as Skype".
  • FiNDME is a UK based non profit organisation for patients and carers with FND and ME.
  • FND Action is a registered charity in England and Wales providing support and information for people with FND.
  • FND Awareness Day is held on April 13th.