Fungal fruit body lectin family

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Fungal fruit body lectin
PDB 1y2u EBI.jpg
crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with lacto-N-biose
Symbol FB_lectin
Pfam PF07367
InterPro IPR009960

In molecular biology, the fungal fruit body lectin family consists of several fungal fruit body lectin proteins. Fruit body lectins are thought to have insecticidal activity [1] and may also function in capturing nematodes.[2] One member of this family, the lectin XCL from Boletus chrysenteron (formerly Xerocomus chrysenteron), induces drastic changes in the actin cytoskeleton after sugar binding at the cell surface and internalisation, and has potent insecticidal activity. The fold of lectin XCL is not related to any of several other lectin folds, but shows significant structural similarity to cytolysins.[3]


  1. ^ Trigueros V, Lougarre A, Ali-Ahmed D, Rahbe Y, Guillot J, Chavant L, Fournier D, Paquereau L (June 2003). "Xerocomus chrysenteron lectin: identification of a new pesticidal protein". Biochim. Biophys. Acta. 1621 (3): 292–8. doi:10.1016/s0304-4165(03)00098-9. PMID 12787928. 
  2. ^ Iijima N, Yoshino H, Ten LC, Ando A, Watanabe K, Nagata Y (October 2002). "Two genes encoding fruit body lectins of Pleurotus cornucopiae: sequence similarity with the lectin of a nematode-trapping fungus". Biosci. Biotechnol. Biochem. 66 (10): 2083–9. doi:10.1271/bbb.66.2083. PMID 12450118. 
  3. ^ Birck C, Damian L, Marty-Detraves C, Lougarre A, Schulze-Briese C, Koehl P, Fournier D, Paquereau L, Samama JP (December 2004). "A new lectin family with structure similarity to actinoporins revealed by the crystal structure of Xerocomus chrysenteron lectin XCL". J. Mol. Biol. 344 (5): 1409–20. doi:10.1016/j.jmb.2004.10.007. PMID 15561152. 

This article incorporates text from the public domain Pfam and InterPro IPR009960