|Preferred IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||114.16 g·mol−1|
|Odor||Roasted coffee, Caramel, Sulfurous, Waxy|
|Density||1.132 g cm−3|
|Boiling point||155 °C; 311 °F; 428 K|
|Vapor pressure||531 Pa|
|Flash point||45 °C (113 °F; 318 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|100-200 mg kg−1 (mouse)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
what is ?)(
Furan-2-ylmethanethiol (2-Furanmethanethiol) is an organic compound containing a furan substituted with a sulfanylmethyl group. It is a clear colourless liquid when pure, but it becomes yellow coloured upon prolonged standing. It possesses a strong odour of roasted coffee and a bitter taste. It is a key component of the aroma of roasted coffee. It has been identified as a trigger molecule for parosmia following COVID-19 infection.
Furan-2-ylmethanethiol is easily prepared by reacting furfuryl alcohol with thiourea in hydrochloric acid via an intermediate isothiouronium salt which is hydrolized to the thiol by heating with sodium hydroxide.
- Parker JK, Kelly CE, Gane SB (5 February 2021). "Molecular Mechanism of Parosmia". medRxiv: 21251085. doi:10.1101/2021.02.05.21251085. S2CID 231843948.
- Devlin H (25 May 2022). "Scientists identify 'trigger molecule' for Covid-related changes to smell". The Guardian.
- "Preparation of furfuryl mercaptane". Organic Syntheses. 35: 66. 1955. doi:10.15227/orgsyn.035.0066.