Fusobacterium

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Fusobacterium
Fusobacterium novum 01.jpg
Fusobacterium novum in liquid culture
Scientific classification e
Kingdom: Bacteria
Phylum: Fusobacteria
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Knorr 1922

Fusobacterium is a genus of anaerobic, Gram-negative, non-sporeforming, bacteria, similar to Bacteroides. Individual cells are slender' rod-shaped bacilli with pointed ends.[1][2] Strains of Fusobacterium cause several human diseases, including periodontal diseases, Lemierre's syndrome, and topical skin ulcers.

Although older sources state that Fusobacterium is part of the normal flora of the human oropharynx, the current consensus is that Fusobacterium should always be treated as a pathogen.[3] F. prausnitzii, a gut commensal associated with healthy patients, was moved out of Fusobacterium into its own genus, Faecalibacterium, in 2002.

Clinical relevance[edit]

In 2011, researchers discovered that Fusobacterium flourishes in colon cancer cells, and is often also associated with ulcerative colitis, although researchers have not determined if the organism actually causes these diseases or if it simply flourishes in the environment these diseases create.[4] The bacterium is a big anchor for biofilms.[5][6]

In contrast to Bacteroides spp., Fusobacterium has a potent lipopolysaccharide.

See also[edit]

References[edit]

  1. ^ Madigan M; Martinko J (editors). (2005). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0-13-144329-1. 
  2. ^ Taber's Cyclopedic Medical Dictionary, 22nd Edition, ISBN 9780803629790, (2009)n p.983
  3. ^ Aliyu SH, Marriott RK, Curran MD, et al. (2004). "Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice". J Med Microbiol. 53 (Pt 10): 1029–35. doi:10.1099/jmm.0.45648-0. PMID 15358827. 
  4. ^ Alice Park (18 October 2011). "A Surprising Link Between Bacteria and Colon Cancer". Time.com. Retrieved 18 October 2011. 
  5. ^ "Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis - Saito - 2007 - Oral Microbiology and Immunology - Wiley Online Library". Oral Microbiology and Immunology. 23: 1–6. doi:10.1111/j.1399-302X.2007.00380.x. 
  6. ^ Okuda, Tamaki; Kokubu, Eitoyo; Kawana, Tomoko; Saito, Atsushi; Okuda, Katsuji; Ishihara, Kazuyuki (Feb 2012). "Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species". Anaerobe. 18 (1): 110–116. doi:10.1016/j.anaerobe.2011.09.003. ISSN 1095-8274. PMID 21945879. 

External links[edit]