Fusobacterium nucleatum

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Fusobacterium nucleatum
Scientific classification e
Domain: Bacteria
Phylum: Fusobacteria
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: F. nucleatum
Binomial name
Fusobacterium nucleatum

Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. This organism is commonly recovered from different monomicrobial and mixed infections in humans and animals. It is a key component of periodontal plaque due to its abundance and its ability to coaggregate with other species in the oral cavity.[1][2] Fusobacterium nucleatum is part of normal, healthy placental microbiome.[3][4]

Preterm births[edit]

Research implicates periodontal disease caused by F. nucleatum with preterm births in humans. In many studies, F. nucleatum cells have been isolated from the amniotic fluid, placenta, and chorioamnionic membranes of women delivering prematurely. Moreover, laboratory mice inoculated with F. nucleatum have been found to deliver prematurely, and the pathology of the infection seems to mirror observations in humans.[5] Together, this research provides strong evidence for a causal connection between F. nucleatum-caused periodontal disease and at least some cases of preterm delivery.

Colonic adenomas[edit]

F. nucleatum has a demonstrated association with colon cancer; in addition, a mechanism has been described by which F. nucleatum induces tumor growth without the more general mechanism of inducing inflammation or otherwise irritating the colon tissue. This suggests direct and specific carcinogenesis.[6]

See also[edit]


  1. ^ Kapatral V; et al. (2002). "Genome sequence and analysis of the oral bacterium 'Fusobacterium nucleatum' strain ATCC 25586.". J Bacteriol. 184 (7): 2005–2018. PMC 134920Freely accessible. PMID 11889109. doi:10.1128/JB.184.7.2005-2018.2002. 
  2. ^ Signat B; et al. (2011). "Fusobacterium nucleatum in Periodontal Health and Disease". Curr Iss Mol Biol. 13 (2): 25–36. 
  3. ^ Mor, Gil; Kwon, Ja-Young (2015). "Trophoblast-microbiome interaction: a new paradigm on immune regulation". American Journal of Obstetrics and Gynecology. 213 (4): S131–S137. ISSN 0002-9378. PMID 26428492. doi:10.1016/j.ajog.2015.06.039. 
  4. ^ Todar, K. "Pathogenic E. coli". Online Textbook of Bacteriology. University of Wisconsin–Madison Department of Bacteriology. Retrieved 2007-11-30. 
  5. ^ http://iai.asm.org/cgi/content/short/72/4/2272
  6. ^ Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS (Aug 14, 2013). "Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment.". Cell host & microbe. 14 (2): 207–15. PMC 3772512Freely accessible. PMID 23954159. doi:10.1016/j.chom.2013.07.007. 

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