Fyn-related kinase

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FRK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDsMGI: 103265 HomoloGene: 48065 GeneCards: FRK
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FRK
Genomic location for FRK
Band6q22.1Start115,931,149 bp[1]
End116,060,891 bp[1]
RNA expression pattern
PBB GE FRK 207178 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002031

NM_001159544
NM_010237
NM_001358769

RefSeq (protein)

NP_002022

NP_001153016
NP_034367
NP_001345698

Location (UCSC)Chr 6: 115.93 – 116.06 MbChr 10: 34.48 – 34.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[5][6]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[6]

Interactions[edit]

FRK has been shown to interact with retinoblastoma protein.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
  6. ^ a b "Entrez Gene: FRK fyn-related kinase".
  7. ^ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Further reading[edit]