Fyn-related kinase

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Fyn-related Src family tyrosine kinase
Symbols FRK ; GTK; PTK5; RAK
External IDs OMIM606573 MGI103265 HomoloGene48065 IUPHAR: 2025 ChEMBL: 4223 GeneCards: FRK Gene
EC number
RNA expression pattern
PBB GE FRK 207178 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2444 14302
Ensembl ENSG00000111816 ENSMUSG00000019779
UniProt P42685 Q922K9
RefSeq (mRNA) NM_002031 NM_001159544
RefSeq (protein) NP_002022 NP_001153016
Location (UCSC) Chr 6:
115.93 – 116.06 Mb
Chr 10:
34.48 – 34.61 Mb
PubMed search [1] [2]

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[1][2]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[2]


FRK has been shown to interact with retinoblastoma protein.[3]


  1. ^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene 138 (1-2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261. 
  2. ^ a b "Entrez Gene: FRK fyn-related kinase". 
  3. ^ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. (UNITED STATES) 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264. 

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