EHMT1

From Wikipedia, the free encyclopedia
  (Redirected from G9a-like protein)
Jump to navigation Jump to search
EHMT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEHMT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1, EHMT1-IT1, KLEFS1
External IDsOMIM: 607001 MGI: 1924933 HomoloGene: 11698 GeneCards: EHMT1
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for EHMT1
Genomic location for EHMT1
Band9q34.3Start137,618,992 bp[1]
End137,870,016 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012518
NM_001109686
NM_001109687
NM_172545

RefSeq (protein)

NP_001012536
NP_001103156
NP_001103157
NP_766133

Location (UCSC)Chr 9: 137.62 – 137.87 MbChr 2: 24.79 – 24.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.[5]

Function[edit]

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition.[5]

Clinical significance[edit]

Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome).[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181090 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036893 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: Euchromatic histone-lysine N-methyltransferase 1". Retrieved 2012-03-04.

Further reading[edit]